DISTRIBUTION OF CAPNOCYTOPHAGA IN PERIODONTAL MICROFLORAS
DISTRIBUTION OF CAPNOCYTOPHAGA IN PERIODONTAL MICROFLORAS
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DOI：
10.1111/j.1600-0765.1985.tb00830.x
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发表时间：
1985-01-01
影响因子：
3.5
通讯作者：
RANNEY, RR
中科院分区：
文献类型：
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作者：
HOLDEMAN, LV;MOORE, WEC;RANNEY, RR
对559例牙周炎(MP)、重度(SP)和局限性青少年(JP)牙周炎患者、健康牙周病患者以及参加实验性牙周炎研究的儿童和成人的559例样本进行了头细胞吞噬作用浓度和发生率的检测。在参与一项实验性牙周炎研究的四名儿童中，突触细胞吞噬现象最常见。MP、SP或JP患者的牙周菌群的发病率和浓度最低。(A)儿童牙周指数(GI)或0高于成人相似部位，(B)GI为2的儿童高于0，(C)健康人的龈上和龈下标本高于SP，(D)SP的龈上和龈下标本高于SP和JP，(E)MP的龈上标本高于SP的龈下标本。这些横断面研究的数据表明，头细胞吞噬在牙周病病因学中的意义被高估了。它们在健康部位和龈上菌群中的发生率和比例高于附着丧失部位的龈下沟，这表明它们在沟内不像在暴露的牙齿表面那样具有竞争力，并反对它们是这些类型破坏性牙周病的活性物质。然而，来自三个参与纵向研究的人(MP)的初步数据显示，在三个人中的一个人中，如果在三个月内至少有2 mm的附着丧失，则其中一个人的口腔真菌水平增加到牙龈下样本中菌群的10%至20%。在另一个人的相似部位没有分离到头细胞吞噬菌，在第三个人的破裂部位，它们占菌群的6%。
Concentrations and incidence of capnocytophagae were determined in 559 samples from persons with moderate (MP), severe (SP), and localized juvenile (JP) periodontitis; persons with healthy gingiva; and children and adults participating in experimental gingivitis studies. Capnocytophagae were most frequent in four children who participated in an experimental gingivitis study. The lowest incidence and concentrations were found in subgingival floras of affected sites of persons with MP, SP, or JP. Statistically significantly (P = 0.02 to 0.05) higher proportions of capnocytophagae were found in (a) sites in children with gingival index (GI) or 0 than similar sites in adults, (b) sites in children with GI of 2 than GI of 0, (c) supragingival and subgingival samples from healthy persons than subgingival samples from SP, (d) supragingival samples from SP than subgingival samples from SP and from JP, (e) supragingival samples from MP than subgingival samples from SP. These data from cross-sectional studies indicate that the significance of capnocytophagae in the etiology of periodontal diseases has been overestimated. Their higher incidence and proportional concentrations in healthy sites and supragingival floras than in the subgingival sulcus of sites with attachment loss would indicate that they are not as competitive in the sulcus as they are on the exposed tooth surface and would argue against their being active agents of these types of destructive periodontal diseases. However, preliminary data from three persons (MP) participating in longitudinal studies show that in one of the three persons the levels of C. ochracea increased to 10 to 20% of the flora in subgingival samples in which there had been at least a 2 mm loss of attachment within three months. No capnocytophagae were isolated from similar sites in one other person, and they constituted 6% of the flora in the breakdown site in the third person.