Effect of α-tocopherol and β-carotene supplementation on the incidence of type 2 diabetes
Effect of α-tocopherol and β-carotene supplementation on the incidence of type 2 diabetes
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DOI：
10.1007/s00125-007-0864-0
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发表时间：
2008-01-01
期刊：
影响因子：
8.2
通讯作者：
Virtamo, J.
中科院分区：
文献类型：
--
作者：
Kataja-Tuomola, M.;Sundell, J. R.;Virtamo, J.
目的/假设2型糖尿病与抗氧化防御能力降低有关。只有少数人类研究调查了抗氧化剂在糖尿病发病机制中的作用。本研究旨在研究α -生育酚或β -胡萝卜素是否影响2型糖尿病的发生。方法：在α -生育酚- β -胡萝卜素癌症预防（ATBC）研究中，一项双盲对照试验，29,133名年龄在50-69岁的男性吸烟者被随机分配接受α -生育酚（50 mg/天）或β -胡萝卜素（20 mg/天）或两种药物或安慰剂，每天5-8年（中位6.1年）。采用高效液相色谱法分析基线血清样品中α -生育酚和β -胡萝卜素的含量。糖尿病病例是从芬兰全国范围内接受糖尿病药物报销的患者登记处确定的。在27379名基线时无糖尿病的男性中，705名男性在长达12.5年的随访期间被诊断患有糖尿病。结果基线血清α -生育酚和β -胡萝卜素水平与安慰剂组糖尿病风险无关：α -生育酚最高和最低五分位数之间的相对风险（RR）为1.59 (95% CI 0.89-2.84)， β -胡萝卜素的相对风险（RR）为0.66 （95% CI 0.40-1.10）。两种补充剂都没有显著影响糖尿病的发病率：与未服用α -生育酚的受试者相比，服用α -生育酚的受试者的RR为0.92 (95% CI 0.79-1.07)，与未服用β -胡萝卜素的受试者相比，服用β -胡萝卜素的受试者的RR为0.99 （95% CI 0.85-1.15）。结论/解释补充α -生育酚和β -胡萝卜素都不能预防男性吸烟者的2型糖尿病。血清α -生育酚和β -胡萝卜素水平与2型糖尿病的风险无关。
Aims/hypothesis Type 2 diabetes is associated with reduced antioxidant defence. Only a few human studies have investigated the role of antioxidants in the pathogenesis of diabetes. This study aimed to examine whether alpha-tocopherol or beta-carotene affected the occurrence of type 2 diabetes.Methods In the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study, a double-blind, controlled trial, 29,133 male smokers aged 50-69 years were randomised to receive either alpha-tocopherol (50 mg/day) or beta-carotene (20 mg/day) or both agents or placebo daily for 5-8 years (median 6.1 years). Baseline serum samples were analysed for alpha-tocopherol and beta-carotene using HPLC. Cases of diabetes were identified from a nationwide Finnish registry of patients receiving drug reimbursement for diabetes. Of 27,379 men without diabetes at baseline, 705 men were diagnosed with diabetes during the follow-up of up to 12.5 years.Results Baseline serum levels of alpha-tocopherol and beta-carotene were not associated with the risk of diabetes in the placebo group: the relative risk (RR) between the highest and lowest quintiles of alpha-tocopherol was 1.59 (95% CI 0.89-2.84) and that for beta-carotene was 0.66 (95% CI 0.40-1.10). Neither supplementation significantly affected the incidence of diabetes: the RR was 0.92 (95% CI 0.79-1.07) for participants receiving alpha-tocopherol compared with non-recipients and 0.99 (95% CI 0.85-1.15) for participants receiving beta-carotene compared with non-recipients.Conclusions/interpretation Neither alpha-tocopherol nor beta-carotene supplementation prevented type 2 diabetes in male smokers. Serum levels of alpha-tocopherol and beta-carotene were not associated with the risk of type 2 diabetes.