Fostering of advanced mutualism with gut microbiota by Immunoglobulin A
Fostering of advanced mutualism with gut microbiota by Immunoglobulin A
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DOI：
10.1111/imr.12384
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发表时间：
2016-03
影响因子：
8.7
通讯作者：
D. Sutherland;Keiichiro Suzuki;S. Fagarasan
中科院分区：
文献类型：
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作者：
D. Sutherland;Keiichiro Suzuki;S. Fagarasan
免疫球蛋白A（伊加）是哺乳动物中分泌量最丰富的抗体同种型，不仅通过母乳为新生儿提供直接的免疫保护，而且还通过调节微生物群来帮助编程婴儿免疫系统。伊加在整个生命过程中继续保持与肠道微生物群的动态相互作用，这影响免疫系统稳态以及其他生理过程。独立于T细胞选择产生的分泌型伊加通常被称为天然或先天抗体。我们的研究表明，先天性伊加虽然能有效地将微生物排除在肠道之外，但不会像在T细胞依赖性生发中心反应中选择的适应性伊加那样促进与微生物群的互利共生。适应性伊加通过选择和多样化有益的微生物群落，与先天性伊加相比，促进了与微生物群的更先进的互利共生。在这篇综述中，我们认为适应性伊加压力导致的多样化微生物群在促进哺乳动物的生态适应性和物种形成潜力方面至关重要。
Immunoglobulin A (IgA), the most abundantly secreted antibody isotype in mammals, not only provides direct immune protection to neonates via maternal milk but also helps program the infant immune system by regulating the microbiota. IgA continues to maintain dynamic interactions with the gut microbiota throughout life and this influences immune system homeostasis as well as other physiological processes. The secretory IgA produced independently of T‐cell selection are commonly referred to as natural or innate antibodies. Our studies have shown that innate‐IgA, while effective at excluding microorganisms from the gut, does not promote mutualism with the microbiota in the same way as adaptive‐IgA that is selected in T cell‐dependent germinal center reactions. Adaptive‐IgA fosters more advanced mutualism with the microbiota than innate‐IgA by selecting and diversifying beneficial microbial communities. In this review, we suggest that the diversified microbiota resulting from adaptive‐IgA pressure was pivotal in promoting ecological adaptability and speciation potential of mammals.