Leukemia-inhibitory factor-neuroimmune modulator of endocrine function.
Leukemia-inhibitory factor-neuroimmune modulator of endocrine function.
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DOI：
10.1210/edrv.21.3.0400
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发表时间：
2000-06
影响因子：
20.3
通讯作者：
C. Auernhammer;S. Melmed
中科院分区：
文献类型：
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作者：
C. Auernhammer;S. Melmed
白血病抑制因子（LIF）是一种由多种组织类型表达的多效性细胞因子。LIF受体与IL-6细胞因子超家族共有一个共同的gp 130受体亚基。LIF信号传导主要由JAK-STAT（Janus激酶信号转导子和转录激活子）途径介导，并被SOCS（细胞因子信号传导抑制子）和皮亚斯（活化STAT的蛋白质抑制剂）蛋白质消除。除了经典的造血和神经元作用，LIF在几种内分泌功能中起关键作用，包括子宫-胎盘单位、下丘脑-垂体-肾上腺轴、骨细胞代谢、能量稳态和卵巢反应性肿瘤。本文综述了近年来我们对LIF表达和作用的分子调控机制的研究进展，并对LIF介导的内分泌调节进行了系统的概述。局部和全身LIF用于整合多种发育和功能细胞信号，最终维持适当的激素和代谢稳态。因此，LIF作为神经免疫和内分泌系统之间的关键分子界面发挥作用。
Leukemia-inhibitory factor (LIF) is a pleiotropic cytokine expressed by multiple tissue types. The LIF receptor shares a common gp130 receptor subunit with the IL-6 cytokine superfamily. LIF signaling is mediated mainly by JAK-STAT (janus-kinase-signal transducer and activator of transcription) pathways and is abrogated by the SOCS (suppressor-of cytokine signaling) and PIAS (protein inhibitors of activated STAT) proteins. In addition to classic hematopoietic and neuronal actions, LIF plays a critical role in several endocrine functions including the utero-placental unit, the hypothalamo-pituitary-adrenal axis, bone cell metabolism, energy homeostasis, and hormonally responsive tumors. This paper reviews recent advances in our understanding of molecular mechanisms regulating LIF expression and action and also provides a systemic overview of LIF-mediated endocrine regulation. Local and systemic LIF serve to integrate multiple developmental and functional cell signals, culminating in maintaining appropriate hormonal and metabolic homeostasis. LIF thus functions as a critical molecular interface between the neuroimmune and endocrine systems.