Rapid prototyping of scaphoid and lunate bones
Rapid prototyping of scaphoid and lunate bones
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DOI：
10.1002/biot.200800233
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发表时间：
2009-01-01
影响因子：
4.7
通讯作者：
Chichkov, Boris N.
中科院分区：
文献类型：
--
作者：
Gittard, Shaun D.;Narayan, Roger J.;Chichkov, Boris N.
在这项研究中，一种新的快速成型技术被用来制造舟状骨和月骨假体，这两种腕骨容易发生缺血性坏死。使用Envisiontec eShell 200光固化聚合物，使用Envisiontec Perfactory（R）SXGA立体光刻系统制造腕关节假体。使用3-D模型引导制造，所述3-D模型使用Mimics软件（Materialise NV，Leuven，Belgium）从患者计算机断层扫描数据生成。以逐层方式制造假体;在假体中观察到类似于50 μ m厚的层。聚合的eShell 200材料的硬度和杨氏模量值分别为93.8 +/- 7.25 MPa和3050 +/- 90 MPa。对于舟骨假体，骨折所需的最小压缩力为1360 N，月骨假体为1248 N。在MTT试验中，聚合Envisiontec eShell材料显示出较高的人新生儿表皮角质形成细胞活力率。本研究的结果表明，使用eShell 200聚合物通过立体光刻制造的小骨假体可能具有适合体内使用的几何形状、机械性能和细胞相容性。
In this study, a novel rapid prototyping technology was used to fabricate scaphoid and lunate bone prostheses, two carpal bones that are prone to avascular necrosis. Carpal prostheses were fabricated with an Envisiontec Perfactory (R) SXGA stereolithography system using Envisiontec eShell 200 photocurable polymer. Fabrication was guided using 3-D models, which were generated using Mimics software (Materialise NV, Leuven, Belgium) from patient computer tomography data. The prostheses were fabricated in a layer-by-layer manner; similar to 50-mu m thick layers were observed in the prostheses. Hardness and Young's modulus values of polymerized eShell 200 material were 93.8 +/- 7.25 MPa and 3050 +/- 90 MPa, respectively. The minimum compressive force required for fracture was 1360 N for the scaphoid prosthesis and 1248 N for the lunate prosthesis. Polymerized Envisiontec eShell material exhibited high human neonatal epidermal keratinocyte cell viability rate in an MTT assay. The results of this study indicate that small bone prostheses fabricated by stereolithography using eShell 200 polymer may have suitable geometry, mechanical properties, and cytocompatibility properties for in vivo use.