Bulk ablation of soft tissue with intense ultrasound: Modeling and experiments
Bulk ablation of soft tissue with intense ultrasound: Modeling and experiments
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DOI：
10.1121/1.2011157
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发表时间：
2005-10-01
影响因子：
2.4
通讯作者：
Slayton, MH
中科院分区：
文献类型：
--
作者：
Mast, TD;Makin, IRS;Slayton, MH
本文介绍了使用强超声进行软组织大块消融的方法，这些方法在局部肿瘤的热治疗中具有潜在的应用。一个近似的分析模型，批量消融预测消融的基础上组织属性，空间平均超声热沉积，灌注的进展。近似模型允许预测体内消融所需的阈值声功率以及比较具有不同起始温度和灌注特性的情况，例如典型的体内和离体实验。在一个完整的三维数值模型中，使用菲涅尔近似计算来自阵列换能器的热沉积，并通过有限差分计算组织中的热传递，考虑由沸腾和热剂量依赖性吸收引起的加热变化。相似的消融趋势，由于灌注效应预测的简单的分析模型和完整的数值模型。与实验结果的比较表明，这两个模型在预测组织消融效果的有效性。由模拟和实验所示的现象包括在体内消融的功率阈值，在体内和离体损伤之间的差异，可比的源条件，组织沸腾和吸收的变化对消融深度的影响，和一个连续的旋转扫描方法的性能适合于软组织的间质大块消融。(c)2005年美国声学学会。
Methods for the bulk ablation of soft tissue using intense ultrasound, with potential applications in the thermal treatment of focal tumors, are presented. An approximate analytic model for bulk ablation predicts the progress of ablation based on tissue properties, spatially averaged ultrasonic heat deposition, and perfusion. The approximate model allows the prediction of threshold acoustic powers required for ablation in vivo as well as the comparison of cases with different starting temperatures and perfusion characteristics, such as typical in vivo and ex vivo experiments. In a full three-dimensional numerical model, heat deposition from array transducers is computed using the Fresnel approximation and heat transfer in tissue is computed by finite differences, accounting for heating changes caused by boiling and thermal dose-dependent absorption. Similar ablation trends due to perfusion effects are predicted by both the simple analytic model and the full numerical model. Comparisons with experimental results show the efficacy of both models in predicting tissue ablation effects. Phenomena illustrated by the simulations and experiments include power thresholds for in vivo ablation, differences between in vivo and ex vivo lesioning for comparable source conditions, the effect of tissue boiling and absorption changes on ablation depth, and the performance of a continuous rotational scanning method suitable for interstitial bulk ablation of soft tissue. (c) 2005 Acoustical Society of America.