Role of CD97(stalk) and CD55 as molecular markers for prognosis and therapy of gastric carcinoma patients.
Role of CD97(stalk) and CD55 as molecular markers for prognosis and therapy of gastric carcinoma patients.
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DOI：
10.1631/jzus.2005.b0913
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发表时间：
2005-09-01
期刊：
影响因子：
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通讯作者：
Hoang-Vu, C
中科院分区：
文献类型：
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作者：
Liu, Yong;Chen, Li;Hoang-Vu, C
目的：通过研究CD97及其细胞配体CD55在胃癌中的表达及作用，探讨其在胃癌发生、发展中的作用。方法：采用免疫组织化学和RT-PCR方法检测39例胃癌组织及相应正常组织中CD97和CD55的表达。CD97(STRK)在I、T1期胃癌组织中表达较多。CD97(茎)在I期与II、III、IV期之间的表达差异有统计学意义(P
OBJECTIVES: To explore the mechanism of development and aggressiveness in gastric carcinomas by investigating the expression and role of CD97 and its cellular ligand CD55 in gastric carcinomas.METHODS: Tumor and corresponding normal mucosal tissue, collected from 39 gastric carcinoma patients, were examined by immunohistochemistry and RT-PCR for the expression of CD97 and CD55.RESULTS: CD97(stalk) was strongly stained on scattered tumor cells or small tumor cell clusters at the invasion front of gastric carcinomas. The expression of CD97(stalk) was frequently observed in tumors of stage I and T1 gastric carcinoma patients. The expression of CD97(stalk) between Stage I and Stage II, III, IV specimens showed significant difference (P