Multi-scale simulations of pulmonary airflow based on a coupled 3D-1D-0D model
Multi-scale simulations of pulmonary airflow based on a coupled 3D-1D-0D model
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DOI：
10.1016/j.compbiomed.2024.108150
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发表时间：
2024-02-16
影响因子：
7.7
通讯作者：
Chen，Xian
中科院分区：
文献类型：
--
作者：
Jiang，Fei;Hirano，Tsunahiko;Chen，Xian
肺气流模拟是研究呼吸功能和疾病的有价值的工具。然而，呼吸系统是一个复杂的多尺度系统，涉及不同的空间和时间尺度的各种物理和生物过程。在这项研究中，我们提出了一个3D-1D-0 D多尺度方法来模拟肺气流，它集成了不同层次的细节和复杂的呼吸系统。该方法由三个部分组成：气管和支气管中气流的3D计算流体动力学模型，终末细支气管中气流的1D管道模型，以及呼吸性细支气管和肺泡中气流与肺变形耦合的0 D双相混合物模型。不同部件之间的耦合通过满足质量和动量守恒定律以及界面处的压力连续条件来实现。通过与以往模型的数据比较，证明了该方法的有效性和适用性。我们还研究了减少吸入空气量由于肺纤维化使用开发的多尺度模型。我们的方法为模拟肺气流提供了一个全面而现实的框架，并可能有助于呼吸系统疾病的诊断和治疗。
Pulmonary airflow simulation is a valuable tool for studying respiratory function and disease. However, the respiratory system is a complex multiscale system that involves various physical and biological processes across different spatial and temporal scales. In this study, we propose a 3D-1D-0D multiscale method for simulating pulmonary airflow, which integrates different levels of detail and complexity of the respiratory system. The method consists of three components: a 3D computational fluid dynamics model for the airflow in the trachea and bronchus, a 1D pipe model for the airflow in the terminal bronchioles, and a 0D biphasic mixture model for the airflow in the respiratory bronchioles and alveoli coupled with the lung deformation. The coupling between the different components is achieved by satisfying the mass and momentum conservation law and the pressure continuity condition at the interfaces. We demonstrate the validity and applicability of our method by comparing the results with data of previous models. We also investigate the reduction in inhaled air volume due to the pulmonary fibrosis using the developed multiscale model. Our method provides a comprehensive and realistic framework for simulating pulmonary airflow and can potentially facilitate the diagnosis and treatment of respiratory diseases.