A potent modifier of liver cancer risk on distal mouse chromosome 1: Linkage analysis and characterization of congenic lines
A potent modifier of liver cancer risk on distal mouse chromosome 1: Linkage analysis and characterization of congenic lines
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DOI：
10.1534/genetics.103.024521
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发表时间：
2004-06-01
期刊：
影响因子：
3.3
通讯作者：
Drinkwater, NR
中科院分区：
文献类型：
--
作者：
Bilger, A;Bennett, LM;Drinkwater, NR
C3 H/HeJ（C3 H）和CBA/J（CBA）小鼠品系是癌症易感性的经典小鼠模型，表现出自发性和化学诱导肝癌的高风险。通过分析C3 H或CBA与抗性B6小鼠之间的回交和互交，我们将肝细胞癌发展的有效修饰因子定位于远端1号染色体，与标记D1 Mit 33连锁，其合并LODw评分类似于5.9（C3 H）和6.5（CBA）。我们以前确定了这个区域作为两个修改易感性在更远的相关C57 BR/cdJ（BR）菌株之一。同源B6.C3H（D1 Mit 5-D1-Mit 17）和B6.BR（D1 Mit 5-D1 Mit 17）小鼠的肝肿瘤发生率显著高于B6小鼠（雄性为6- 13倍，P < 10（-11）;雌性为3- 4倍，P < 10（-3））。因此，远端1号染色体携带一个或多个足以赋予肝癌易感性的基因。
The C3H/HeJ (C3H) and CBA/J (CBA) mouse strains are classical mouse models of cancer-susceptibility, exhibiting high risks for both spontaneous and chemically induced liver cancer. By analysis of backcrosses and intercrosses between C3H or CBA and resistant B6 mice, we have mapped a potent modifier of hepatocellular carcinoina development to distal chromosome 1, linked to the marker D1Mit33 with combined LODw scores of similar to5.9 (C3H) and 6.5 (CBA). We previously identified this region as one of two that modify susceptibility in the more distantly related C57BR/cdJ (BR) strain. Congenic B6.C3H(D1Mit5-D1-Mit17 and B6.BR(D1Mit5-D1Mit17) mice developed significantly more liver tumors than B6 mice did (6- to 13-fold, P < 10(-11), in males; 3- to 4-fold, P < 10(-3), in females). Thus, distal chromosome 1 carries one or more genes that are sufficient to confer susceptibility to liver cancer.