SARS-CoV-2 variants evolved during the early stage of the pandemic and effects of mutations on adaptation in Wuhan populations.
SARS-CoV-2 variants evolved during the early stage of the pandemic and effects of mutations on adaptation in Wuhan populations.
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DOI：
10.7150/ijbs.47827
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发表时间：
2021
影响因子：
9.2
通讯作者：
Zhang W
中科院分区：
文献类型：
--
作者：
Awadasseid A;Wu Y;Tanaka Y;Zhang W
2019年冠状病毒病(新冠肺炎)的暴发是由严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)引起的。疫情显然始于2019年12月的武汉，中国，自那以来已经影响了世界上的许多国家，成为一个重大的全球威胁。中国研究人员报告称，SARS-CoV-2可以分为两个主要变种。他们建议，调查这些变种的变异和特征可能有助于评估风险，并制定更好的治疗和预防策略。这两个变异体分别命名为L型和S型，其中L型在中国所在的湖北省武汉市首次暴发流行，S型在系统发育上比L型更古老，在早期流行较少，但在武汉出现的频率较晚。在103个已测序的SARS-CoV-2基因组中，有149个突变，其中83个为非同义突变，导致蛋白质的氨基酸序列发生改变。目前正在致力于阐明这些突变是否会影响病毒的传播性和毒力。本文对SARS-CoV-2在病毒进化早期的变异进行了综述，并讨论了基因变异在感染中的意义。
The outbreak of the coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The pandemic apparently started in December 2019 in Wuhan, China, and has since affected many countries worldwide, turning into a major global threat. Chinese researchers reported that SARS-CoV-2 could be classified into two major variants. They suggest that investigating the variations and characteristics of these variants might help assess risks and develop better treatment and prevention strategies. The two variants were named L-type and S-type, in which L-type was prevailed in an initial outbreak in Wuhan, Central China's Hubei Province, and S-type was phylogenetically older than L-type and less prevalent at an early stage, but with a later increase in frequency in Wuhan. There were 149 mutations in 103 sequenced SARS-CoV-2 genomes, 83 of which were nonsynonymous, leading to alteration in the amino acid sequence of proteins. Much effort is currently being devoted to elucidate whether or not these mutations affect viral transmissibility and virulence. In this review, we summarize the mutations in SARS-CoV-2 during the early phase of virus evolution and discuss the significance of the gene alterations in infections.
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影响因子：
158.5
作者：
Li, Qun;Guan, Xuhua;Feng, Zijian
通讯作者：
Feng, Zijian
影响因子：
64.8
作者：
Jebb D;Huang Z;Pippel M;Hughes GM;Lavrichenko K;Devanna P;Winkler S;Jermiin LS;Skirmuntt EC;Katzourakis A;Burkitt-Gray L;Ray DA;Sullivan KAM;Roscito JG;Kirilenko BM;Dávalos LM;Corthals AP;Power ML;Jones G;Ransome RD;Dechmann DKN;Locatelli AG;Puechmaille SJ;Fedrigo O;Jarvis ED;Hiller M;Vernes SC;Myers EW;Teeling EC
通讯作者：
Teeling EC
DOI：
10.1126/science.abc0870
发表时间：
2020-09-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Chan KK;Dorosky D;Sharma P;Abbasi SA;Dye JM;Kranz DM;Herbert AS;Procko E
通讯作者：
Procko E
影响因子：
3.3
作者：
Lapinsky, Stephen E;Granton, John T
通讯作者：
Granton, John T
影响因子：
4.7
作者：
Brielle, Esther S.;Schneidman-Duhovny, Dina;Linial, Michal
通讯作者：
Linial, Michal