Spinal cord injury - Promising interventions and realistic goals
Spinal cord injury - Promising interventions and realistic goals
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DOI：
10.1097/01.phm.0000086994.53716.17
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发表时间：
2003-10-01
影响因子：
3
通讯作者：
Becker, D
中科院分区：
文献类型：
--
作者：
McDonald, JW;Becker, D
长期以来，脊髓修复一直被认为是不可能的，随着弥合长凳和床边之间差距的努力指向新的治疗方法，脊髓修复正在接近现实。必须认识到，研究领域正在迅速变化，需要新的资源开发机制，才能有效地从基础科学发现过渡到有效的临床治疗。本文综述了神经和非神经细胞移植的最新实验室研究和第一阶段临床试验，强调从基础科学向临床应用的过渡需要并行而不是连续的方法，通过评估和优化，最有效地将基础科学成果转化为临床治疗。回顾了一个动员内源性干细胞用于修复的例子，强调了基础科学在临床治疗中的快速应用。从基础科学到临床应用的成功和有效的过渡需要(1)并行而不是连续的方法；(2)发展整合了翻译、过渡和临床试验三个科学领域的中心；以及(3)开发新的资源，为过渡到临床试验最关键的有限步骤提供资金。
Long regarded as impossible, spinal cord repair is approaching the realm of reality as efforts to bridge the gap between bench and bedside point to novel approaches to treatment. It is important to recognize that the research playing field is rapidly changing and that new mechanisms of resource development are required to effectively make the transition from basic science discoveries to effective clinical treatments. This article reviews recent laboratory studies and phase 1 clinical trials in neural and nonneural cell transplantation, stressing that the transition from basic science to clinical applications requires a parallel rather than serial approach, with continuous, two-way feedback to most efficiently translate basic science findings, through evaluation and optimization, to clinical treatments. An example of mobilizing endogenous stem cells for repair is reviewed, with emphasis on the rapid application of basic science to clinical therapy. Successful and efficient transition from basic science to clinical applications requires (1) a parallel rather than a serial approach; (2) development of centers that integrate three spheres of science, translational, transitional, and clinical trials; and (3) development of novel resources to fund the most critically limited step of transitional to clinical trials.