Effects of human insulin-like growth factor-I on release of growth hormone by rainbow trout (Oncorhynchus mykiss) pituitary cells.
Effects of human insulin-like growth factor-I on release of growth hormone by rainbow trout (Oncorhynchus mykiss) pituitary cells.
复制标题
人胰岛素样生长因子-I 对虹鳟鱼（Oncorhynchus mykiss）垂体细胞释放生长激素的影响。
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
P. L. Bail
中科院分区：
文献类型：
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作者：
J. Pérez;C. Weil;P. L. Bail
将重组人胰岛素样生长因子-I（rhIGF-I）应用于虹鳟鱼垂体细胞的原代培养。在含有3 × 10（4）和6 × 10（4）细胞/孔的威尔斯孔中，rhIGF-I在短时间（6 h）和长时间（12和24 h）暴露时均抑制基础GH释放。GH释放的下降在0.01和100 mM的范围内呈剂量依赖性。rhIGF-I和低浓度的合成生长抑素（SRIF）的组合增强了rhIGF-I的抑制作用的添加剂的方式。未证明rhIGF-I对PRL释放有任何明显影响。据我们所知，这份报告首次证明了IGFs对鱼类GH调节的抑制成分的参与。
A recombinant human IGF-I (rhIGF-I) was applied to primary cultures of rainbow trout pituitary cells. In wells containing 3 x 10(4) and 6 x 10(4) cells/well, rhIGF-I inhibited basal GH release both in short (6 h) and long (12 and 24 h) exposures. The decline in GH release was dose-dependent over the range of 0.01 and 100 mM. The combination of rhIGF-I and low concentrations of synthetic somatostatin (SRIF) enhanced the inhibitory effect of rhIGF-I in an additive manner. Any appreciable effect of rhIGF-I on PRL release was not evidenced. To our knowledge, this report demonstrates for the first time the participation of IGFs on the inhibitory component of fish GH regulation.
非哺乳动物血清的胰岛素样生长因子 I 和 II。
影响因子：
2.7
作者：
Daughaday,WH;Kapadia,M;Yanow,CE;Fabrick,K;Mariz,IK
通讯作者：
Mariz,IK
影响因子：
56.9
作者：
BERELOWITZ, M;SZABO, M;HINTZ, RL
通讯作者：
HINTZ, RL