MicroRNAs (miRNAs) in the control of HF development and cycling: the next frontiers in hair research.

MicroRNAs (miRNAs) in the control of HF development and cycling: the next frontiers in hair research.
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DOI:
10.1111/exd.12785
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发表时间:
2015-11
影响因子:
3.6
通讯作者:
Botchkareva NV
Botchkareva NV
中科院分区:
医学2区
文献类型:
--
作者:
Andl T;Botchkareva NV

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毛囊发育及其产后再生的特点是其微观解剖结构和细胞活性的剧烈变化,这些变化受多种信号通路、转录因子和表观遗传调控因子(包括microRNAs)的控制。mirna及其靶标形成了非常多样化的调控网络,在毛囊不同细胞系的基因表达程序的执行中起着关键作用。本文综述了mirna在毛囊发育、循环和头发色素沉着控制中的作用,强调了尚未解决的问题,并提出了这一快速发展和令人兴奋的研究领域的未来方向。
Hair follicle development and its postnatal regeneration are characterized by dramatic changes in its microanatomy and cellular activity, which are controlled by multiple signalling pathways, transcription factors and epigenetic regulators, including microRNAs (miRNAs). miRNAs and their targets form remarkably diverse regulatory networks, playing a key role in the execution of gene expression programmes in the different cell lineages of the hair follicle. This review summarizes the roles of miRNAs in the control of hair follicle development, cycling and hair pigmentation, emphasizes the remaining problems/unanswered questions, and provides future directions in this rapidly growing and exciting area of research.
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