Agonal hepatic arterial vasospasm.
Agonal hepatic arterial vasospasm.
复制标题
临终肝动脉血管痉挛。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
F. Belzer
中科院分区：
文献类型：
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作者：
A. D'Alessandro;R. Stratta;Southard Jh;M. Kalayoglu;F. Belzer
在猪窒息模型中研究了供体预处理二苄啉（苯氧苯扎明）对肝动脉血管痉挛的影响。九头猪在没有预处理的情况下接受了肝切除术，而六头猪在肝解剖前给予每公斤 2 毫克的二苄林。用电磁流量探头监测肝动脉血流，心脏骤停后获得肝循环动脉图。第 1 组中的 7 头猪发生肝动脉血管痉挛，第 2 组中只有 1 头猪发生肝动脉血管痉挛（p 小于 0.05）。在窒息期间，经过预处理的猪的临终肝动脉血流量保持恒定（415 +/- 30 毫升每分钟），但在未经预处理的猪中显着减少（98.6 +/- 63.3 毫升每分钟）（p 小于 0.05）。本研究的结果证明了肝动脉血管痉挛的临终发生及其用二苄林的预防。在临床器官获取中可能需要使用α-肾上腺素能拮抗剂对供体进行预处理，以防止临终动脉血管痉挛及其对早期同种异体移植肝功能的潜在不利影响。
The effect of donor pretreatment with Dibenzyline (phenoxybenzamine) on hepatic arterial vasospasm was studied in a porcine asphyxia model. Nine pigs underwent hepatectomy without pretreatment, while six were given 2 milligrams per kilogram of Dibenzyline prior to hepatic dissection. Hepatic arterial blood flow was monitored with an electromagnetic flow probe, and after cardiac arrest, arteriograms of the hepatic circulation were obtained. Hepatic arterial vasospasm occurred in seven of the pigs in group 1 and in only one of group 2 (p less than 0.05). Agonal hepatic arterial blood flow remained constant (415 +/- 30 milliliters per minute) in pretreated pigs during asphyxia, but was markedly reduced (98.6 +/- 63.3 milliliters per minute) in nonpretreated pigs (p less than 0.05). Results of this study demonstrate the agonal occurrence of hepatic arterial vasospasm and its prevention with Dibenzyline. Donor pretreatment with alpha-adrenergic antagonists may be indicated in clinical organ procurement to prevent agonal arterial vasospasm and its potentially adverse effect on early hepatic allograft function.