The atopic march: progression from atopic dermatitis to allergic rhinitis and asthma.
The atopic march: progression from atopic dermatitis to allergic rhinitis and asthma.
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DOI：
10.4168/aair.2011.3.2.67
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发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Zhu Z
中科院分区：
文献类型：
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作者：
Zheng T;Yu J;Oh MH;Zhu Z
特应性皮炎（AD）是一种以瘙痒性皮肤损害为特征的炎症性疾病。 AD 的发病机制可能包括表皮屏障功能破坏、免疫失调以及 IgE 介导的对食物和环境过敏原的过敏。 AD 也是特应性进展过程的一部分，即从 AD 进展到过敏性鼻炎和哮喘。这得到了多项横断面和纵向研究以及实验数据的支持。 AD 机制的研究主要集中在适应性免疫系统，重点是 T 辅助细胞 1 (Th1)-Th2 范式。最近，概念焦点已在很大程度上转移到将上皮屏障的主要缺陷作为 AD 的初始事件，为疾病的发生提供了重要的见解，并指出环境和免疫后遗症与屏障破坏之间复杂的继发相互作用。对 AD 的进一步了解将有助于开发更有效的 AD 治疗方法，并最终有助于开发特应性游行的预防算法。在这篇综述中，我们重点介绍了我们对 AD 发病机制和特应性进展的理解的最新进展。
Atopic dermatitis (AD) is an inflammatory disease characterized by pruritic skin lesions. The pathogenesis of AD may include disrupted epidermal barrier function, immunodysregulation, and IgE-mediated sensitization to food and environmental allergens. AD is also part of a process called the atopic march, a progression from AD to allergic rhinitis and asthma. This has been supported by multiple cross-sectional and longitudinal studies and experimental data. Research on the mechanisms of AD has been centered on the adaptive immune system with an emphasis on the T-helper 1 (Th1)-Th2 paradigm. Recently, the conceptual focus has largely shifted to include a primary defect in the epithelial barrier as an initial event in AD providing a significant insight into the disease initiation and pointing to a complex secondary interplay of environmental and immunological sequelae with barrier disruption. Further understanding of AD will help the development of more effective treatment for AD and ultimately, preventative algorithms for the atopic march. In this review we highlight recent advances in our understanding of the pathogenesis of AD and the atopic march.