Hepatitis C virus coinfection and superinfection
Hepatitis C virus coinfection and superinfection
复制标题
DOI：
10.1086/510858
复制
发表时间：
2007-02-15
影响因子：
6.4
通讯作者：
Sherman, Kenneth E.
中科院分区：
文献类型：
--
作者：
Blackard, Jason T.;Sherman, Kenneth E.
RNA病毒的一个特点是其极端的遗传多样性。在个体内，丙型肝炎病毒（HCV）以不同但密切相关的病毒变体群体的形式存在，称为“病毒准种”。这些变异可能表现出不同的复制能力、细胞趋向性、免疫逃逸和抗病毒药物耐药性。同时感染两种或两种以上不同的hcv已被经常记录。此外，最近还报告了几例丙型肝炎病毒重复感染。然而，关于合并感染和重复感染的临床后果的数据很少，尽管这些现象对丙型肝炎疫苗的设计和开发以及丙型肝炎治疗剂的疗效具有重要意义。
A hallmark of RNA viruses is their extreme genetic diversity. Within an individual, the hepatitis C virus (HCV) exists as a population of distinct but closely related viral variants, termed the "viral quasispecies." These variants may display divergent replicative capacity, cell tropism, immunologic escape, and antiviral-drug resistance. Coinfection with 2 or more distinct HCVs has been frequently documented. Moreover, several cases of HCV superinfection have been reported recently. However, few data are available regarding the clinical consequences of coinfection and superinfection, although these phenomena have important implications for HCV vaccine design and development, as well as for the efficacy of HCV therapeutic agents.