Serum free fatty acid concentration in patients with acute pancreatitis
Serum free fatty acid concentration in patients with acute pancreatitis
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DOI：
10.1159/000055816
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发表时间：
2001-01-01
期刊：
影响因子：
3.6
通讯作者：
Panek, J
中科院分区：
文献类型：
--
作者：
Sztefko, K;Panek, J
背景：脂肪酶和游离脂肪酸参与急性胰腺炎（AP）的病理学研究。目的：分析AP患者游离脂肪酸水平与病情严重程度的关系。材料与方法：本研究纳入急性水肿性AP 36例（I组），坏死性AP 29例，无并发症AP 16例（IIA组），合并并发症AP 13例（IIB组），对照组12例。入院后4天内测定血清总游离脂肪酸水平（酶法）和游离脂肪酸池中单个脂肪酸水平（气液色谱法）。结果：各治疗组平均血清总游离脂肪酸均显著升高，且均在入院时达到最高值（p < 0.02 ~ 0.01）。油酸（I组，p < 0.02， IIA组，p < 0.05， IIB组，p < 0.005）、亚油酸（IIB组，p < 0.02）和花生四烯酸（IIA组，p < 0.05， IIB组，p < 0.02）的贡献率显著高于对照组。硬脂酸（3组：p < 0.01, p < 0.005, p < 0.01）和棕榈酸（仅IIB组：p < 0.005）的百分比显著降低。仅IIB组每天的饱和与多不饱和脂肪酸比值显著低于对照组（p < 0.005-p < 0.001）。结论：以亚油酸和花生四烯为主的多不饱和脂肪酸可能参与了急性胰腺炎并发症的发生。版权所有(C) 2001 S. Karger AG，巴塞尔和IAP。
Background: The involvement of lipolytic enzymes and liberated fatty acids in ethiology of acute pancreatitis (AP) has been implicated. Aim: To analyze the level of FFA in the patients with AP in relation to severity of the disease. Material and Methods: The study included 36 patients with acute edematous AP (group I), 29 patients with necrotizing AP: 16 without (group IIA) and 13 with complications (group IIB), and 12 control subjects. Serum levels of total FFA (by enzymatic method) and the individual fatty acids of the FFA pool (by gas-liquid chromatography) were measured during the first 4 days after admission. Results: A significant increase in the mean total serum FFA was noted for all the groups with the highest values on admission (p < 0.02-0.01). The per cent contribution was significantly higher as compared to control group for oleic acid (group I, p < 0.02, group IIA, p < 0.05, group IIB, p < 0.005), linoleic acid (group IIB, p < 0.02) and arachidonic acid (group IIA, p < 0.05, group IIB, p < 0.02). Significantly lower percentage was noted for stearic acid (all three groups: p < 0.01, p < 0.005, p < 0.01, respectively) and for palmitic acid (only group IIB: p < 0.005). The ratio of saturated to polyunsaturated fatty acids was significantly lower than in control group on each day of study for group IIB only (p < 0.005-p < 0.001). Conclusion: Polyunsaturated fatty acids, mainly linoleic and arachidonic, may be involved in the development of complications in acute pancreatitis. Copyright (C) 2001 S. Karger AG, Basel and IAP.