Epidemiology of Bacteremia in Febrile Infants Aged 60 Days and Younger.
Epidemiology of Bacteremia in Febrile Infants Aged 60 Days and Younger.
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DOI：
10.1016/j.annemergmed.2017.07.488
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发表时间：
2018-03
影响因子：
6.2
通讯作者：
Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network (PECARN)
中科院分区：
文献类型：
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作者：
Powell EC;Mahajan PV;Roosevelt G;Hoyle JD Jr;Gattu R;Cruz AT;Rogers AJ;Atabaki SM;Jaffe DM;Casper TC;Ramilo O;Kuppermann N;Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network (PECARN)
描述儿科急诊应用研究网络（PECARN）中≤ 60日龄发热婴儿菌血症的流行病学现状。我们对一项前瞻性观察性研究进行了一项计划的次要分析，该研究涉及2008年至2013年在26个PECARN急诊科（ED）就诊并获得血培养的≤ 60天发热婴儿。我们排除了有显著合并症或危重病表现的婴儿。主要结局是菌血症的患病率。在7，335名接受筛查的婴儿中，4，778名（65.1%）进行了血培养并入选。其中，84例有菌血症（1.8%; 95% CI 1.4-2.2%）。≤ 28日龄婴儿（47/1，515）的菌血症患病率为3.1%（95% CI 2.3-4.1%），29-60日龄婴儿（37/3，246）的菌血症患病率为1.1%（95% CI 0.8-1.6%）。对于≤ 28天的婴儿，患病率因周龄而异（0-7天：4/156，2.6%），（8-14天：19/356，5.3%），（15-21天：15/449，3.3%），（22-28天：9/554，1.6%）。最常见的病原体是大肠埃希菌（39.3%; 95% CI 29.5-50.0%）和B组链球菌（23.8%; 95% CI 16.0-33.9%）。19/1515例≤ 28日龄婴儿（1.3%; 95% CI 0.8-2.0%）和5/3,246例29-60日龄婴儿（0.2%; 95% CI 0.1-0.4%）发生细菌性脑膜炎。在84例菌血症婴儿中，36例（42.9%; 95%CI 32.8-53.5%）有尿路感染（大肠埃希菌83%）; 11例（13.1%; 95%CI 7.5-21.9%）有细菌性脑膜炎。在≤ 28天的发热婴儿中，菌血症和脑膜炎的患病率很高，超过了在29-60天的婴儿中观察到的患病率。大肠杆菌和B组链球菌是最常见的细菌病原体。
To describe the current epidemiology of bacteremia in febrile infants ≤ 60 days-old in the Pediatric Emergency Care Applied Research Network (PECARN). We conducted a planned secondary analysis of a prospective observational study of febrile infants ≤ 60 days-old presenting to any of 26 PECARN emergency departments (EDs) (2008 –2013) who had blood cultures obtained. We excluded infants with significant comorbidities or critically-ill appearances. The primary outcome was prevalence of bacteremia. Of 7,335 screened infants, 4,778 (65.1%) had blood cultures and were enrolled. Of these, 84 had bacteremia (1.8%; 95% CI 1.4–2.2%). The prevalence of bacteremia in infants ≤ 28 days-old (47/1,515) was 3.1% (95% CI 2.3–4.1%) and in infants 29–60 days-old (37/3,246) was 1.1% (95% CI 0.8–1.6%). Prevalence differed by week of age for infants ≤ 28 days (0–7 days: 4/156, 2.6%), (8–14 days: 19/356, 5.3%), (15–21 days: 15/449, 3.3%), (22–28 days: 9/554, 1.6%). The most common pathogens were Escherichia coli (39.3%; 95% CI 29.5–50.0%) and group B streptococcus (23.8%; 95% CI 16.0–33.9%). Bacterial meningitis occurred in 19/1515 infants ≤ 28 days-old (1.3%; 95% CI 0.8–2.0%) and 5/3,246 infants 29–60 days-old (0.2%; 95% CI 0.1–0.4%). Of 84 infants with bacteremia, 36 (42.9%; 95% CI 32.8–53.5%) had urinary tract infections (Escherichia coli 83%); 11 (13.1%; 95%CI 7.5–21.9%) had bacterial meningitis. The prevalence of bacteremia and meningitis among febrile infants ≤ 28 days-old is high and exceeds that observed in infants 29–60 days old. Escherichia coli and group B streptococcus are the most common bacterial pathogens.
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影响因子：
1.4
作者：
Mahajan P;Kuppermann N;Suarez N;Mejias A;Casper C;Dean JM;Ramilo O;Febrile Infant Working Group for the Pediatric Emergency Care Applied Research Network (PECARN)
通讯作者：
Febrile Infant Working Group for the Pediatric Emergency Care Applied Research Network (PECARN)
影响因子：
3.6
作者：
Greenhow, Tara L.;Hung, Yun-Yi;Pantell, Robert H.
通讯作者：
Pantell, Robert H.
影响因子：
120.7
作者：
Mahajan, Prashant;Kuppermann, Nathan;Ramilo, Octavio
通讯作者：
Ramilo, Octavio
影响因子：
8
作者：
Greenhow, Tara L.;Hung, Yun-Yi;Herz, Arnd M.
通讯作者：
Herz, Arnd M.
影响因子：
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作者：
Bhansali, Priti;Wiedermann, Bernhard L;Shah, Neha
通讯作者：
Shah, Neha