Differential involvement of protein tyrosine kinases p56lck and p59fyn in T cell development.
Differential involvement of protein tyrosine kinases p56lck and p59fyn in T cell development.
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蛋白酪氨酸激酶 p56lck 和 p59fyn 在 T 细胞发育中的差异参与。
DOI：
10.1007/978-1-4615-3396-2_12
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发表时间：
1992
影响因子：
--
通讯作者：
H. Teh
中科院分区：
文献类型：
--
作者：
N. V. van Oers;A. Garvin;M. Cooke;C. Davis;D. Littman;R. Perlmutter;H. Teh
Mature CD4+ and CD8+ T cells recognize and respond to processed antigens associated with major histocompatibility complex-encoded molecules (MHC). It is during thymic development that selection processes act on immature CD4+CD8+ thymocytes to ensure the fonnation of a repertoire of functional T cells1,2. Thus, immature T cells expressing an ∝β TCR with specificity for self-peptides plus MHC class I or class II molecules are positively selected, differentiating into CD8+ or CD4+ T cells, respectively3,4,5,6. Immature thymocytes lacking or expressing a non-selectable TCR undergo programmed cell death1. Additionally, those CD4+CD8+ T cells expressing an autospecific TCR may undergo programmed cell death 7,8 (negative selection). The CD4 and CD8 molecules are thought to actively participate in these T cell repertoire selection events through their coreceptor functions9. In a coreceptor model, the TCR and appropriate coreceptor molecule recognize and interact with the same MHC molecule, with CD4 or CD8 potentiating TCR-derived intracellular signals10,1l.12. Recent reports have demonstrated that mutations affecting CD8/class I MHC interactions disrupt both positive and negative selection in the thymus13,14.
T 细胞抗原受体同种异型决定簇特异性鼠单克隆抗体的表征。
DOI：
--
发表时间：
1985
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Staerz,UD;Rammensee,HG;Benedetto,JD;Bevan,MJ
通讯作者：
Bevan,MJ
CD4 与 T 细胞受体的物理关联。
DOI：
--
发表时间：
1992
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Dianzani,U;Shaw,A;al-Ramadi,BK;Kubo,RT;JanewayJr,CA
通讯作者：
JanewayJr,CA
fyn 原癌基因的新型形式在造血细胞中的表达。
DOI：
--
发表时间：
1989
期刊：
The New biologist
影响因子：
--
作者：
Cooke,MP;Perlmutter,RM
通讯作者：
Perlmutter,RM