Naltrexone decreases D-amphetamine and ethanol self-administration in rhesus monkeys
Naltrexone decreases D-amphetamine and ethanol self-administration in rhesus monkeys
复制标题
DOI：
10.1097/fbp.0b013e3283423d55
复制
发表时间：
2011-02-01
影响因子：
1.6
通讯作者：
Woods, James H.
中科院分区：
文献类型：
--
作者：
Jimenez-Gomez, Corina;Winger, Gail;Woods, James H.
Amphetamines are the second most highly abused illicit drugs worldwide, yet there is no pharmacological treatment for amphetamine abuse and dependence. Preclinical studies and, more recently, human studies, suggest that the opioid receptor antagonist, naltrexone, might be useful in the treatment of amphetamine abuse. Naltrexone, an opioid receptor antagonist, is currently used for the treatment of alcohol dependence. The aim of this study was to explore the ability of naltrexone to modify self-administration of amphetamine or ethanol in rhesus monkeys. Monkeys were trained to respond to intravenous injections of either D-amphetamine (0.003 mg/kg/injection) or ethanol (0.05 g/kg/injection) on a fixed ratio 30 schedule. Naltrexone (0.01-1 mg/kg) was administered intramuscularly 30 min before the start of treatment test sessions. Naltrexone dose-dependently decreased both amphetamine and ethanol self-administration. These findings support the potential use of naltrexone as therapy for amphetamine and polydrug abuse. Behavioural Pharmacology 22: 87-90 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
