APPARENT INCREASE IN THE INCIDENCE OF INVASIVE GROUP-A BETA-HEMOLYTIC STREPTOCOCCAL DISEASE IN CHILDREN
APPARENT INCREASE IN THE INCIDENCE OF INVASIVE GROUP-A BETA-HEMOLYTIC STREPTOCOCCAL DISEASE IN CHILDREN
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DOI：
10.1016/s0022-3476(05)82144-4
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发表时间：
1991-03-01
影响因子：
5.1
通讯作者：
WASILAUSKAS, B
中科院分区：
文献类型：
--
作者：
GIVNER, LB;ABRAMSON, JS;WASILAUSKAS, B
最近，在成年人中，由A组β-溶血性链球菌（GABS）引起的侵袭性疾病的发病率有所增加，一种称为“中毒性休克样综合征”的严重疾病也是由GABS引起的。我们现在报告，从1987年开始，GABS在儿童中引起的侵袭性疾病的发病率明显增加。在这些患者中，表现是多种多样的。一名儿童的体征和症状符合链球菌中毒性休克样综合征。在我们患者的GABS分离株中，8/10（80%）的M-蛋白抗原评价为不可分型。GABS的血清型与毒力之间的关系有待进一步研究。医生应该意识到儿童侵袭性GABS疾病发病率增加的可能性，以及其表现，其中可能包括中毒性休克样综合征。
Recently, among adults, an increase in the incidence of invasive disease caused by group A beta-hemolytic streptococci (GABS) has been noted, as has the appearance of a severe illness called "toxic shock-like syndrome", also caused by GABS. We now report an apparent increase beginning in 1987 in the incidence of invasive disease caused by GABS in children. Among these patients the manifestations were varied. One child had signs and symptoms compatible with the streptococcal toxic shock-like syndrome. Among the GABS isolates from our patients, 8 (80%) of 10 evaluated for M-protein antigens were nontypeable. Further studies will be necessary to determine the relationship between serotypes and virulence of GABS. Physicians should be aware of the possibility of an increasing incidence of invasive GABS disease in children, as well as its manifestations, which may include toxic shock-like syndrome.