Two different mechanisms of calcium spike modulation by dopamine
Two different mechanisms of calcium spike modulation by dopamine
复制标题
多巴胺调节钙尖峰的两种不同机制
DOI：
10.1523/jneurosci.05-09-02522.1985
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发表时间：
1985
影响因子：
3.8
通讯作者：
H. Gerschenfeld
中科院分区：
文献类型：
--
作者：
D. Paupardin;L. Colombaioni;P. Deterre;H. Gerschenfeld
多巴胺（10至50 μ M）以两种不同的方式调节记录在蜗牛Haplaspersa的已识别神经元的细胞体中的Ca 2+依赖性动作电位的持续时间。在一些神经元（细胞E13和F1）中，多巴胺通过降低S-电流来增加它们的Ca 2+依赖性尖峰平台的幅度（Klein，M.，J.S. Camardo和E. R. Kandel（1982）Proc. Natl. Acad. Sci. U.S.A. 79：5713-5717），由环AMP控制的K+电流。在另一个神经元（细胞D2）中，多巴胺通过引起由Ca 2+电导降低引起的Ca 2+电流降低来降低体细胞动作电位的Ca 2+依赖性平台。这两种调节作用可以在同一个神经元中观察到，其中多巴胺诱导的Ca 2+电导和环AMP依赖的K+电导的降低。然而，在这些细胞（如细胞F5）多巴胺只引起钙峰平台的幅度下降。由于在神经元索马中记录的Ca ~（2+）动作电位的持续时间的调制已被证明构成了在突触末梢发生的事件的良好模型，因此建议多巴胺诱发的这些调制机制可能参与突触前易化和抑制的过程。
Dopamine (10 to 50 microM) modulates in two different ways the duration of the Ca2+-dependent action potential recorded in the cell body of identified neurons of the snail Helix aspersa. In some neurons (cells E13 and F1) dopamine increases the amplitude of their Ca2+-dependent spike plateau by decreasing the S-current (Klein, M., J.S. Camardo, and E. R. Kandel (1982) Proc. Natl. Acad. Sci. U.S.A. 79: 5713–5717), a K+ current controlled by cyclic AMP. In another neuron (cell D2), dopamine decreases the Ca2+-dependent plateau of the somatic action potential by evoking a decrease in Ca2+-current resulting from a decrease in Ca2+ conductance. Both modulatory effects could be observed in the same single neuron in which dopamine induces decreases of both the Ca2+ conductance and cyclic AMP-dependent K+ conductance. Nevertheless, in these cells (such as cell F5) dopamine only evokes a decrease of the amplitude of the Ca2+ spike plateau. Since the modulation of the duration of the Ca2+ action potential recorded in the neuronal soma has been shown to constitute a good model of events taking place at synaptic endings, it is suggested that these modulatory mechanisms evoked by dopamine may be involved in processes of presynaptic facilitation and inhibition.
DOI：
10.1073/pnas.77.12.7492
发表时间：
1980-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
CASTELLUCCI, VF;KANDEL, ER;GREENGARD, P
通讯作者：
GREENGARD, P