Early heartburn relief with proton pump inhibitors: a systematic review and meta-analysis of clinical trials.
Early heartburn relief with proton pump inhibitors: a systematic review and meta-analysis of clinical trials.
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使用质子泵抑制剂缓解早期胃灼热：临床试验的系统评价和荟萃分析。
DOI：
10.1016/s1542-3565(05)00023-6
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
L. Laine
中科院分区：
文献类型：
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作者：
K. Mcquaid;L. Laine
背景与目的质子泵抑制剂（PPIs）常用于短期治疗胃灼热。我们对PPIs治疗头1-2天内缓解胃灼热的疗效进行了系统评价。方法检索文献数据库，查找PPIs用于胃灼热患者的临床试验，提供1-2天胃灼热缓解比例的信息。计算完全或持续（连续7天）缓解的患者的样本量加权合并比例。还进行了ppi随机比较的meta分析。结果18项试验符合纳入标准。在PPI治疗的第1天，有0.31（95%可信区间[CI]， 0.30-0.32）、0.49 （95% CI, 0.48-0.50）、0.55 （95% CI, 0.53-0.56）和0.21 （95% CI, 0.20-0.22）的患者出现了完全的24小时、白天、夜间和持续的胃灼热缓解。在28天的ppi治疗中，有37%的胃灼热缓解发生在第1天。在第1天的24小时缓解中，安慰剂的效果明显低于PPI（相对危险度[RR]， 0.41; 95% CI, 0.29-0.58），单剂量PPI治疗的效果低于双剂量PPI治疗（RR, 0.82; 95% CI, 0.74-0.92）。结论：大约30%的患者在首次服用PPI后一整天的胃灼热完全缓解，9%的患者在首次服用安慰剂后一整天的胃灼热完全缓解（安慰剂与PPI第一天缓解的RR为0.41 [95% CI, 0.28-0.58]）。虽然质子泵抑制剂可能在治疗的第一天提供益处，但大多数患者在质子泵抑制剂治疗1或2天后症状不会缓解。
Background & AimsProton pump inhibitors (PPIs) are often taken for short-term treatment of heartburn. We performed a systematic review of the efficacy of PPIs for heartburn relief within the first 1–2 days of therapy.MethodsBibliographic databases were searched for clinical trials of PPIs in patients with heartburn that provided information about the proportion with heartburn relief at day 1–2. The sample size-weighted pooled proportions of patients with complete or sustained (7 consecutive days) relief were calculated. Meta-analyses of randomized comparisons of PPIs were also performed.ResultsEighteen trials met inclusion criteria. At day 1 of PPI therapy, complete 24-hour, daytime, nighttime, and sustained heartburn relief occurred in 0.31 (95% confidence interval [CI], 0.30–0.32), 0.49 (95% CI, 0.48–0.50), 0.55 (95% CI, 0.53–0.56), and 0.21 (95% CI, 0.20–0.22) of patients. Up to 37% of the heartburn relief achievable with 28 days of PPIs occurred on day 1. Placebo was significantly less effective than PPIs for 24-hour relief on day 1 (relative risk [RR], 0.41; 95% CI, 0.29–0.58), and single-dose PPI therapy was less effective than double-dose therapy (RR, 0.82; 95% CI, 0.74–0.92).ConclusionsComplete heartburn relief for the entire day occurs in approximately 30% of patients after their first PPI dose and 9% of patients after their first placebo (RR for relief on day 1 for placebo versus PPI was 0.41 [95% CI, 0.28–0.58]). Although PPIs might provide benefit from the first day of therapy, most patients will not have symptom relief with 1 or 2 days of PPI therapy.
反流性食管炎患者的症状缓解：
DOI：
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发表时间：
2003
期刊：
J Gastroenterol Hepatol 18
影响因子：
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作者：
Adachi K;et al.
通讯作者：
et al.