A Synthetic Method for Site-Specific Functionalized Polypeptides: Metal-Free, Highly Active, and Selective at Room Temperature
A Synthetic Method for Site-Specific Functionalized Polypeptides: Metal-Free, Highly Active, and Selective at Room Temperature
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一种位点特异性功能化多肽的合成方法：无金属、高活性、室温选择性
DOI：
10.1002/anie.202009316
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Hadjichristidis Nikos
中科院分区：
文献类型：
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作者：
Zhao Wei;Lv Yanfeng;Li Ji;Feng Zihao;Ni Yonghao;Hadjichristidis Nikos
功能化多肽由于其可调节的物理化学特性，包括亲水性和刺激响应行为，近年来引起了人们的极大兴趣，并发现了许多刺激应用。开发新的策略来生产这些无金属污染物的聚合物对于其在高价值和敏感领域的应用至关重要，例如生物医学，微电子，食品包装和个人美容护理领域。本文通过将Michael反应与NCA的氢键有机催化ROP相结合，开发了一种高效的策略来获取定义明确的位点特异性功能化多肽。用这种方法可以很容易地制备具有预先设计分子量和低多分散度的链端和链中功能化多肽库（14个例子）。具体来说，整个合成过程不含金属，在室温下具有高活性和选择性。
Functionalized polypeptides have attracted tremendous interest in recent years and found many stimulating applications owing to their tunable physicochemical characteristics including hydrophilicity and stimuli-responsive behavior. The development of new strategies to produce these polymers without metallic contaminants is crucial for their applications in high-value and sensitive domains, such as biomedical, microelectronic, food-packaging, and personal beauty care fields. Herein, a highly efficient strategy to access well-defined site-specific functionalized polypeptides is developed by combining Michael reaction with hydrogen-bonding organocatalytic ROP of NCA. A library of chain-end and chain-middle functionalized polypeptides (14 examples) with predesigned molecular weights and low polydispersities are readily prepared with this approach. Specifically, the whole synthetic process is metal-free, fulfilling high activity and selectivity at room temperature.