Prevalence and clinical characteristics of obstructive- and central-dominant sleep apnea in candidates of catheter ablation for atrial fibrillation in Japan
Prevalence and clinical characteristics of obstructive- and central-dominant sleep apnea in candidates of catheter ablation for atrial fibrillation in Japan
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DOI：
10.1016/j.ijcard.2018.01.103
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发表时间：
2018-06-01
影响因子：
3.5
通讯作者：
Takatsuki, Seiji
中科院分区：
文献类型：
--
作者：
Kohno, Takashi;Kimura, Takehiro;Takatsuki, Seiji
简介：我们的目的是研究的患病率和类型的睡眠呼吸暂停（SA），以及他们的临床特点，在房颤（AF）消融candidateinJapan.Methods：导管消融术前，197个连续的AF患者（年龄：60 +/- 9岁，体重指数; 25.0 +/- 3.0）进行了评估与便携式多导生理记录仪。我们比较了临床特征，根据SA的严重程度以及其类型，如阻塞的存在和混合与中枢性呼吸暂停indics.Results定义：平均呼吸暂停低通气指数（AHI）为17.7 +/- 11.9，135例AF患者的AHI >= 10（68.5%）。AHI >= 10的患者体重指数、血浆脑利钠肽（BNP）水平、高血压患病率和左心房大小显著较高。在AHI ≥ 10的患者中，阻塞型SA的发生率为60.9%，中枢型SA的发生率为7.6%。阻塞型SA患者的高血压患病率显著较高（阻塞型vs中心型：48.3% vs 20.0%，P=0.038）。阻塞性呼吸暂停指数与血浆BNP水平和年龄相关，但中央和混合性呼吸暂停指数没有。结论：SA的患病率是常见的AF消融候选人，即使没有肥胖的流行病，SA型主要是阻塞性的。便携式多导超声心动图可用于检测房颤消融候选者中未确诊的SA患者。(c)2018 Elsevier B. V.版权所有。
Introduction: We aimed to study the prevalence and types of sleep apnea (SA) as well as their clinical characteristics in atrial fibrillation (AF) ablation candidates in Japan.Methods: Before catheter ablation, 197 consecutive AF patients (age: 60 +/- 9 years, body mass index; 25.0 +/- 3.0) were evaluated with portable polygraphy. We compared the clinical characteristics, according to the severity of SA as well as its types, as defined by the presence of obstruction and the mixed vs. central apnea indices.Results: The mean apnea-hypopnea index (AHI) was 17.7 +/- 11.9, with 135 AF patients having an AHI >= 10 (68.5%). Patients with an AHI >= 10 had a significantly higher body mass index, plasma brain natriuretic peptide (BNP) level, prevalence of hypertension, and larger left atrial size. Among patients with an AHI >= 10, the incidence of obstructive-dominant SA was 60.9% and that of central-dominant SA was 7.6%. The prevalence of hypertension was significantly higher in obstructive-dominant SA patients (obstructive vs. central: 48.3% vs. 20.0%, P=0.038). The obstructive apnea index correlated with plasma BNP level and age, but the central and mixed apnea indices did not.Conclusions: The prevalence of SA was common in AF ablation candidates, even without an obesity epidemic, and the SA type was predominantly obstructive. Portable polygraphy was useful for detecting undiagnosed SA patients in AF ablation candidates. (c) 2018 Elsevier B.V. All rights reserved.