Quantitative observations on mineralized and non-mineralized bone in the iliac crest
Quantitative observations on mineralized and non-mineralized bone in the iliac crest
复制标题
髂嵴矿化骨和非矿化骨的定量观察
DOI：
10.1136/jcp.25.4.277
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发表时间：
1972
影响因子：
3.4
通讯作者：
K. Peart
中科院分区：
文献类型：
--
作者：
H. A. Ellis;K. Peart
在68名对照受试者的尸检中，采用点计数法测量了未钙化的髂骨薄切片中矿化骨和类骨的数量。在髂骨脱钙切片中，研究了定量研究所选择的不同位置对获得的总骨量值的影响。总骨量在一个相当恒定的范围内呈现个体差异，50岁前平均为22.7±0.5%，50岁至50岁时逐渐下降至15.5±1.1%。最低值在7 ~ 90岁的老年妇女中为5.5% ~ 16.4（平均为8.9±1.9%）。由此得出结论，所谓老年性骨质疏松症通常是正常衰老过程的表现。在对照组中，类骨仅占测量面积的0.1%，最多占骨的1.8%，平均矿化率为99.5%。骨样呈斑片状分布，任一缝内双折射片最多4片。在髂嵴不同部位进行的定量组织学结果表明，随着距离前上棘的距离和嵴表面以下的深度而变化。讨论了这与用于定量组织学的髂骨活检的位置和大小有关的重要性。在未钙化切片中使用点计数技术和使用骨块的体积法估计的总骨量值之间存在显著的相关性。
The amounts of mineralized bone and osteoid in thin undecalcified sections of iliac crest have been measured in 68 control subjects at necropsy using a point-counting method. The effect of varying the site selected for quantitative study on the value obtained for total bone mass has been investigated in decalcified sections of iliac crest. The total bone mass shows individual variation within a fairly constant range with a mean of 22·7 ± 0·5% up to the age of 50 years and then progressively falls to a mean of 15·5 ± 1·1% for individuals aged > 50 years. Some of the lowest values in the range 5·5 to 16·4 (mean 8·9 ± 1·9%) were observed in elderly women in the seventh to ninth decades. It is concluded that so-called senile osteoporosis is usually a manifestation of a normal aging process. In controls osteoid accounts for only about 0·1% of the area measured and for a maximum of 1·8% of bone with a mean mineralization of 99·5%. Osteoid is patchily distributed and the maximum number of birefringent lamellae in any seam is four. The results of quantitative histology carried out in different parts of the iliac crest indicate that there are variations with the distance of the site from the anterior superior spine and its depth below the crest surface. The importance of this in relation to the site and size of iliac crest biopsies used for quantitative histology is discussed. There is a significant correlation between the values for total bone mass when estimated by the point-counting technique in undecalcified sections and by a volumetric method using blocks of bone.