Quality compared to quantity of life in laryngeal cancer: A time trade-off study
Quality compared to quantity of life in laryngeal cancer: A time trade-off study
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DOI：
10.1002/hed.24061
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发表时间：
2016-04-01
影响因子：
2.9
通讯作者：
Wilson, Janet A.
中科院分区：
文献类型：
--
作者：
Hamilton, David W.;Bins, Janneke E.;Wilson, Janet A.
背景本研究的目的是利用时间权衡来评估影响晚期喉癌患者决策的因素。时间权衡是一种行之有效的方法，评估个人如何价值的特定健康状态。我们开发了描绘放化疗或喉切除术后生活的小插曲。114名参与者对它们进行排名，分配效用值，并评估生存对治疗选择的重要性。62%首选放化疗，38%首选喉切除术。放化疗最佳结果的平均效用值最高（0.64），其次是全喉切除术最佳结果（0.56）。全喉切除术预后不良（0.33）与放化疗预后不良（0.32）相当。参与者改变首选所需的平均生存优势为2.1年。结论。功能治疗结果对健康状态效用值的影响大于治疗方式。在许多个体中，喉保护可能不是治疗偏好的主要考虑因素。(C)2015 Wiley Periodicals，Inc.
Background. The purpose of this study was to use time trade-off to assess the factors influencing patients' decisions in advanced laryngeal cancer. Time trade-off is a well-established method of assessing how individuals value a particular health state.Methods. We developed vignettes depicting life after chemoradiotherapy or laryngectomy. One hundred fourteen participants ranked them, assigned utility values, and rated the importance of survival on treatment choice.Results. Chemoradiotherapy was preferred by 62% and laryngectomy by 38%. Chemoradiotherapy optimal outcome had the highest mean utility value (0.64) followed by total laryngectomy optimal outcome (0.56). Total laryngectomy poor outcome (0.33) was equivalent to chemoradiotherapy poor outcome (0.32). The average survival advantage required for a participant to change their preferred choice was 2.1 years.Conclusion. The functional treatment outcome had a greater effect on health state utility values than treatment modality. In many individuals, larynx conservation may not be the primary consideration in treatment preference. (C) 2015 Wiley Periodicals, Inc.