The use of solid-state image sensor technology to detect and characterize live mammalian cells growing in tissue culture.
The use of solid-state image sensor technology to detect and characterize live mammalian cells growing in tissue culture.
复制标题
使用固态图像传感器技术来检测和表征组织培养中生长的活哺乳动物细胞。
DOI：
--
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
B. Jaggi
中科院分区：
文献类型：
--
作者：
B. Palcic;B. Jaggi
参数提出，大约30 000个细胞必须在一个单一的实验中测量低剂量生存测定放射生物学参数。为此，需要一种能够以1 cm 2/min的速率检测和识别单个未染色的活哺乳动物细胞的全自动装置。这样一个系统的规格推导和证据表明，这可以最好地进行使用固态图像传感器的光电探测器的线性阵列的形式。这种设备的设计和其他潜在用途的轮廓进行了讨论。
Arguments are presented that approximately 30 000 cells have to be measured in a single experiment to measure radiobiological parameters in a low-dose survival assay. For this purpose, a fully automated device capable of detecting and recognizing individual live unstained mammalian cells at a rate of 1 cm2/min is required. Specifications of such a system are derived and evidence is presented which suggests that this can best be carried out using a solid-state image sensor in the form of a linear array of photodetectors. The outline of the design and other potential uses of such a device are discussed.