IDENTIFICATION OF AN INHIBITOR OF NEOVASCULARIZATION FROM CARTILAGE
IDENTIFICATION OF AN INHIBITOR OF NEOVASCULARIZATION FROM CARTILAGE
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DOI：
10.1126/science.1694043
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发表时间：
1990-06-15
期刊：
影响因子：
56.9
通讯作者：
LANGER, R
中科院分区：
文献类型：
--
作者：
MOSES, MA;SUDHALTER, J;LANGER, R
某些组织如软骨对血管的侵袭具有抵抗力，但目前还没有单一的组织来源的分子能够抑制血管生成的报道。在这些单独的生物测定中，纯化了来自软骨的蛋白质，其抑制体内血管生成和体外毛细血管内皮细胞增殖和迁移。该蛋白也是哺乳动物胶原酶的抑制剂。这些发现可能有助于阐明在正常和病理状态下控制新生血管形成的机制。
Certain tissues such as cartilage are resistnat to vascular invasion, yet no single tissue-derived molecule that can inhibit angiogenesis has been reported. A protein, derived from cartilage was purified that inhibits angiogenesis in vivo and capillary endothelial cell proliferation and migration in vitro in these separate bioassays. The protein is also an inhibitor of mammalian collagenase. These findings may help elucidate the mechanisms by which neovascularization is controlled in both normal and pathological states.