Kinetic tremor: Differences between smokers and non-smokers
Kinetic tremor: Differences between smokers and non-smokers
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DOI：
10.1016/j.neuro.2006.12.006
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发表时间：
2007-05-01
期刊：
影响因子：
3.4
通讯作者：
Louis, Elan D.
中科院分区：
文献类型：
--
作者：
Louis, Elan D.
震颤是尼古丁暴露的急性效应之一。已发表的研究集中在吸烟相关的姿势（静态）手震颤，而不是运动性震颤（手使用过程中的震颤），吸烟相关震颤的性别差异尚未得到检查。在从人群中取样的一组成年人中（平均值+/- S.D. = 65.7 +/- 11.5岁，范围= 18-92岁），研究者评估了吸烟者与非吸烟者之间姿势性和动力性震颤的严重程度是否不同，以及这种差异是否受性别的影响。273例受试者中有27例（9.9%）目前吸烟。在各种活动中，吸烟者比非吸烟者的震颤更大（画螺旋、用勺子、指-鼻-指手法，均P < 0.05）和吸烟者的总震颤评分高于非吸烟者（5.15 +/- 3.06对3.41 +/- 2.88，p < 0.01），即使调整了年龄，咖啡因摄入量和其他潜在的混杂因素。吸烟者和不吸烟者之间手震颤的差异在女性中比男性更明显。在女性中，测试当天吸烟的数量与震颤总评分弱相关（r = 0.17，p = 0.03）。总之，吸烟者比不吸烟者有更多的动力性手震颤。吸烟者和不吸烟者之间的这种差异在妇女中比在男子中更明显。这些结果表明，吸烟习惯应仔细考虑，以避免过度或低估的影响，职业和非职业暴露于其他震颤产生的神经毒素。(c)2006年爱思唯尔公司All rights reserved.
Tremor is among the acute effects of nicotine exposure. Published studies have focused on smoking-related postural (static) hand tremor rather than kinetic tremor (tremor during hand use), and gender differences in smoking-related tremor have not been examined. In a group of adults who were sampled from a population (mean +/- S.D. = 65.7 +/- 11.5 years, range = 18-92 years), the investigator assessed whether the severity of postural and kinetic tremors differed in smokers versus non-smokers, and whether this difference was influenced by gender. Twenty-seven (9.9%) of 273 subjects were current smokers. Greater tremor was observed in smokers than non-smokers during a variety of activities (drawing a spiral, using a spoon, finger-nose-finger maneuver, all p < 0.05) and smokers had a higher total tremor score than non-smokers (5.15 +/- 3.06 versus 3.41 +/- 2.88, p < 0.01), even after adjusting for age, caffeine intake and other potential confounding factors. The difference between smokers and non-smokers in terms of hand tremor was more apparent in women than in men. In women, the number of cigarettes smoked on the day of testing was weakly correlated with the total tremor score (r = 0.17, p = 0.03). In summary, smokers had more kinetic hand tremor than non-smokers. This difference between smokers and non-smokers was more apparent in women than in men. These results suggest that smoking habits should be considered carefully in order to avoid over- or underestimating the effects of occupational and non-occupational exposures to other tremor-producing neurotoxins. (c) 2006 Elsevier Inc. All rights reserved.