Effects of X-ray irradiation on hearing in guinea pigs.
Effects of X-ray irradiation on hearing in guinea pigs.
复制标题
X 射线照射对豚鼠听力的影响。
作者：
T. Tokimoto;K. Kanagawa
从照射后即刻到数周，连续观察X射线照射对CM和ABR气导和骨导刺激听力的影响。在2、4和6krad时，只有轻微的传导性听力损害，但在8krad或更高时，CM和ABR在短暂增加后突然消失。重度感音神经性听力损失出现在8krad照射结束后约10h，10krad照射结束后约6h，12krad照射结束后约3h。频率越高，听力损害越严重，耳内直流电越强。10krad照射后7h左右，电位(EP)下降。在组织学上，10krad照射后6h左右，扫描电子显微镜下未见毛细胞或感觉毛细胞的明显变化，而透射电子显微镜下可见耳蜗基底部的外毛细胞大部分被破坏。但内毛细胞或其他支持细胞未见变化。
Effects of X-ray irradiation on the hearing with CM and ABR to both air- and bone-conduction stimuli were studied continuously from immediately after the irradiation to a few weeks later. At 2, 4, and 6 krad, only slight conductive hearing impairment was found, but at 8 krad or more, CM and ABR disappeared abruptly, after having increased briefly. Advanced sensorineural hearing loss appeared at about 10 hours after irradiation ended at 8 krad, at about 6 hours at 10 krad, and at about 3 hours at 12 krad. More severe hearing impairment was observed at higher frequencies and the endocochlear d.c. potential (EP) decreased at about 7 hours after 10 krad irradiation. Histologically, no discernible changes in the hair cells or sensory hairs were found with a scanning electron microscope at about 6 hours after 10 krad irradiation, while with a transmission electron microscope, the outer hair cells in the basal coil of the cochlea were found to be mostly destroyed. However, no changes could be found in the inner hair cells or other supporting cells.