Human trophoblast cells are permissive to the complete replicative cycle of human cytomegalovirus
Human trophoblast cells are permissive to the complete replicative cycle of human cytomegalovirus
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DOI：
10.1128/jvi.72.9.7598-7602.1998
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发表时间：
1998-09-01
影响因子：
5.4
通讯作者：
Sinzger, C
中科院分区：
文献类型：
--
作者：
Halwachs-Baumann, G;Wilders-Truschnig, M;Sinzger, C
人滋养层细胞被人巨细胞病毒允许感染。与成纤维细胞相比，病毒立即早期、早期和晚期基因表达的动力学明显延迟。通过检测病毒粒子、滋养层培养上清液中的感染性病毒以及巨细胞病毒从感染的滋养层到未感染的成纤维细胞的细胞间传播，明确证明了生产性感染。这些观察结果表明，感染的滋养层细胞可能参与人巨细胞病毒的母婴传播。
Human trophoblast cells were permissively infected by human cytomegalovirus. The kinetics of viral immediate-early, early, and late gene expression was clearly delayed compared to that in fibroblasts, Productive infection was unequivocally proven by the detection of virion particles, infectious virus in trophoblast culture supernatant, and cell-to-cell spread of cytomegalovirus from infected trophoblasts to uninfected fibroblasts. These observations indicate that infected trophoblasts may be involved in maternofetal transmission of human cytomegalovirus.