Prevalence and Associations of Epiretinal Membranes in a Rural Chinese Adult Population: The Handan Eye Study
Prevalence and Associations of Epiretinal Membranes in a Rural Chinese Adult Population: The Handan Eye Study
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DOI：
10.1167/iovs.08-2624
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发表时间：
2009-05-01
影响因子：
4.4
通讯作者：
Wong, Tien Yin
中科院分区：
文献类型：
--
作者：
Duan, Xin Rong;Liang, Yuan Bo;Wong, Tien Yin
目的。通过视网膜摄影和光学相干断层扫描 (OCT) 评估，确定中国人群中视网膜前膜 (ERM) 的患病率和相关性。方法。邯郸眼科研究是一项针对中国 30 岁以上农村地区眼病的人群研究。符合条件的居民接受了详细的眼科检查，包括视网膜摄影和 Stratus OCT。 ERM 通过视网膜照片和 OCT 的组合来定义，并根据视网膜照片特征分为玻璃纸黄斑反射 (CMR) 或视网膜前黄斑纤维化 (PMF)。 结果。在接受检查的 6830 人中，6565 人 (96.1%) 进行了可分级的视网膜照片和/或 OCT。平均年龄为 51.7 +/- 11.6 岁。 3.4%（95% CI：2.9% +/- 3.8%）的参与者存在 ERM，其中 20.3% 的病例存在双侧 ERM。 2.2% 存在 CMR，0.7% 存在 PMF，0.5% 存在未分类的 ERM（仅通过 OCT 检测）。女性和男性的 ERM 患病率相似（3.6% vs. 3.1%），与年龄增长密切相关（趋势 P < 0.001）。调整年龄和性别后，主要 ERM 与近视呈正相关（OR：1.58，95% CI：1.12-2.23），与当前吸烟呈负相关（OR：0.61，95% CI：0.38 - 0.97，与从不吸烟相比）。调整年龄、性别和晶状体状态后，患有原发性 ERM 的眼睛的最佳矫正视力明显较差（平均 LogMAR 评分低 0.07，95% CI：0.05-0.10），而没有 ERM 的眼睛则较差。结论。 ERM 影响了中国农村 30 岁以上人口的 3.4%。特发性 ERM 与近视、视力下降有关，与吸烟呈负相关。 （投资眼科可见科学。2009；50：2018-2023）DOI：10.1167/iovs.08-2624
PURPOSE. To determine the prevalence and association of epiretinal membranes (ERMs), as assessed by retinal photography and optical coherence tomography (OCT), in a Chinese population.METHODS. The Handan Eye Study is a population-based study of eye disease in rural Chinese aged 30+ years. Eligible residents underwent a detailed ophthalmic examination including retinal photography and Stratus OCT. ERMs were defined by a combination of retinal photographs and OCT and classified as cellophane macular reflex (CMR) or preretinal macular fibrosis (PMF) based on retinal photographs characteristics.RESULTS. Of the 6830 persons examined, 6565 (96.1%) had gradable retinal photographs and/or OCT. The mean age was 51.7 +/- 11.6 years. ERMs were present in 3.4% (95% CI: 2.9% +/- 3.8%) of participants, bilateral in 20.3% of the cases. CMR was present in 2.2% and PMF in 0.7%, and ERMs were unclassified in 0.5% (detected by OCT only). ERM prevalence was similar in women and men (3.6% vs. 3.1%), strongly associated with increasing age (P for trend < 0.001). After adjustment for age and sex, primary ERM was associated positively with myopia (OR: 1.58, 95% CI: 1.12- 2.23) and inversely with current smoking (OR: 0.61, 95% CI: 0.38 - 0.97, versus never smoked). Best corrected visual acuity was significantly worse in eyes with primary ERMs (mean LogMAR score lower by 0.07, 95% CI: 0.05-0.10) than eyes without ERMs, after adjustment for age, sex, and lens status.CONCLUSIONS. ERMs affect 3.4% of the population 30+ years of age and living in rural China. Idiopathic ERMs were associated with myopia, decreased visual acuity, and inversely associated with smoking. (Invest Ophthalmol Vis Sci. 2009;50:2018-2023) DOI:10.1167/iovs.08-2624