Human herpesvirus 6: Infection and disease following autologous and allogeneic bone marrow transplantation
Human herpesvirus 6: Infection and disease following autologous and allogeneic bone marrow transplantation
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DOI：
10.1182/blood.v87.12.5341.bloodjournal87125341
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发表时间：
1996-06-15
期刊：
影响因子：
20.3
通讯作者：
Armstrong, JA
中科院分区：
文献类型：
--
作者：
Kadakia, MP;Rybka, WB;Armstrong, JA
对15例异基因骨髓移植患者和11例自体骨髓移植患者进行了人类疱疹病毒6型(HHV-6)活性检测。移植后，26例患者中有12例(异体6例，自体6例)外周血中分离到HHV-6。移植前26例患者中有11例出现唾液中HHV-6 DNA脱落，12例患者中有12例出现唾液脱落。26例患者中有7例抗体滴度升高。因此，26名患者中有23名通过病毒分离、唾液脱落或抗体滴度增加而显示出HHV-6感染活跃的证据。19例患者唾液标本阳性率与抗体滴度呈负相关(P=0.005)。移植后培养阳性的比例增加(P=0.007)。在自体受者中，鼻窦炎与HHV-6分离相关(P=0.002)。在异基因患者中，人类巨细胞病毒活动性感染与HHV-6分离相关(P=0.04)。未发现HHV-6感染与移植物抗宿主病、肺炎、植入延迟或骨髓抑制有关。在分析了26名患者的120起临床事件中，根据HHV-6活动的可能性和临床事件加上没有其他已确定的事件原因，HHV-6被定义为9名患者16起事件的可能原因。
Human herpesvirus 6 activity (HHV-6) was studied in 15 allogeneic and 11 autologous marrow transplantation patients. After transplantation, HHV-6 was isolated from the peripheral blood mononuclear cells of 12 of 26 patients (6 allogeneic and 6 autologous). All isolates were variant B. Eleven of 26 and 12 of 19 patients showed salivary shedding of HHV-6 DNA before and after transplantation, respectively. The antibody titer increased in 7 of 26 patients. Thus, 23 of 26 patients showed evidence of active HHV-6 infection either by virus isolation, salivary shedding, or increases in antibody titers. The fraction of saliva specimens positive in 19 patients was negatively associated with their antibody titers (P = .005). The proportion of cultures positive increased after transplantation (P = .007). Sinusitis was associated with HHV-6 isolation in autologous recipients(P = .002). In allogeneic patients, active human cytomegalovirus infection was associated with HHV-6 isolation (P = .04). No association was observed between HHV-6 infection and GVHD, pneumonia, delay in engraftment, or marrow suppression. Of the 120 clinical events analyzed in 26 patients, HHV-6 was defined as a probable cause of 16 events in 9 patients based on the propinquity of HHV-6 activity and the clinical event plus the absence of other identified causes of the event.