EFFECTS OF TAXOL ON SLOW AND FAST AXONAL-TRANSPORT
EFFECTS OF TAXOL ON SLOW AND FAST AXONAL-TRANSPORT
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DOI：
10.1002/cm.970110302
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发表时间：
1988-01-01
影响因子：
--
通讯作者：
TASHIRO, T
中科院分区：
文献类型：
--
作者：
KOMIYA, Y;TASHIRO, T
一次松果体下注射紫杉醇几乎完全抑制大鼠坐骨神经微管蛋白的轴突运输，而不影响神经丝蛋白的轴突运输。肌动蛋白和大量与肌动蛋白共运输的多肽作为次要成分也被紫杉醇阻断，尽管程度较小。快速轴突转运基本上不受该药物的抑制作用。虽然以前的模型表明，缓慢的轴突运输涉及细胞骨架结构的整体移动，但这些结果表明，这种运输可能涉及轴突细胞骨架聚合和解聚形式之间的平衡。
Axonal transport of tubulin in the rat sciatic nerve is almost completely inhibited by a single subepineural injection of taxol, without affecting that of neurofilament proteins. Actin and a large number of polypeptides cotransported with actin as minor components are also blocked by taxol, although to a lesser extent. Fast axonal tranport is essentially free from the inhibitory effect of this drug. Although previous models have suggested that slow axonal tranport involves the bulk movement of cytoskeletal structures, these results suggest that such transport may involve an equlibrium between polymerised and depolymerised forms of the axonal cytoskeleton.