Preliminary study of a new growing rod system in immature swine model
Preliminary study of a new growing rod system in immature swine model
复制标题
新型幼猪生长棒系统的初步研究
DOI：
10.1016/j.wneu.2019.02.112
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发表时间：
2019
影响因子：
2
通讯作者：
Jianxiong Shen
中科院分区：
文献类型：
--
作者：
Chong Chen;Fan Feng;Haining Tan;Zheng Li;Zhihai Zhang;Jinqian Liang;Xingye Li;Jianxiong Shen
BackgroundGrowing棒技术已被证明是一个有价值的治疗在早发性脊柱侧凸，然而，重复的手术和全身麻醉不能避免的MethodsThis研究包括12个未成熟的猪被随机分配到一个新的增长棒系统（实验组）或传统的增长棒系统（对照组）。每隔4周进行一次延长，总观察期为12周。射线照相术，计算机断层扫描，和运动分析的脊柱进行评估棒的延伸，增长和非融合的脊柱，和fixation.ResultsOne猪（对照组）被排除在分析，因为在1周后的深度伤口感染的初步操作。在其余11头猪中未观察到并发症。实验组平均延长时间为12.1 ± 3.1 min，平均切口长度为1.1 ± 0.2 cm，均明显小于对照组（P< 0.001）。在初次手术前或最终评估时（术后12周;P> 0.05），两组的平均躯干长度、体重或头侧或尾侧固定椎体和椎间盘厚度均无显著性差异。脊柱的生长和运动的仪器脊柱segments.ConclusionsThe新的增长棒系统是安全和有效的未成熟的猪，保留脊柱的生长潜力，涉及较少的手术创伤。
BackgroundGrowing rod techniques have been demonstrated to be a valuable treatment in early-onset scoliosis; however, repeated surgeries and general anesthesia cannot be avoided.MethodsThis study included 12 immature swine that were randomly assigned to receive either a novel growing rod system (experimental group) or a traditional growing rod system (control group). Lengthening was undertaken at 4-week intervals, for a total observation period of 12 weeks. Radiography, computed tomography, and motion analysis of the spine were conducted to evaluate rod extension, growth and nonfusion of the spine, and fixation.ResultsOne swine (control group) was excluded from the analysis because of a deep wound infection at 1 week after the initial operation. No complications were observed in the remaining 11 swine. In the experimental group, the average lengthening operation lasted 12.1 ± 3.1 minutes, and average incision length was 1.1 ± 0.2 cm; both values were significantly less compared with the control group (P< 0.001). No significant between-group differences in mean trunk length, body mass, or thickness of cephalad-instrumented or caudad-instrumented vertebrae and intervertebral disks were present before the initial operation or at the final assessment (12 weeks after operation;P> 0.05). Spinal growth and motion of instrumented spinal segments were conserved.ConclusionsThe novel growing rod system is safe and effective in immature swine, preserving spine growth potential and involving less surgical trauma.