Health care costs and mortality associated with nosocomial diarrhea due to Clostridium difficile
Health care costs and mortality associated with nosocomial diarrhea due to Clostridium difficile
复制标题
DOI：
10.1086/338260
复制
发表时间：
2002-02-01
影响因子：
11.8
通讯作者：
Kelly, CNP
中科院分区：
文献类型：
--
作者：
Kyne, L;Hamel, MB;Kelly, CNP
对271例患者进行前瞻性随访，以确定住院期间并发艰难梭菌腹泻的患者与住院期间未并发艰难梭菌腹泻的患者相比，在费用、住院时间和生存率方面是否存在差异。艰难梭菌相关性腹泻40例患者（15%）发生院内C。艰难梭菌相关性腹泻这些患者的调整后住院费用为3669美元--即54%（95%置信区间[CI]，17%-103%）--比病程未并发C.艰难梭菌相关性腹泻由于C.艰难梭菌相关性腹泻为3.6天（95% CI，1.5-6.2）。C.在调整年龄、合并症和疾病严重程度后，艰难梭菌相关腹泻与3个月或1年死亡率无关。根据这项研究的结果，保守估计，美国每年因这种疾病造成的费用超过11亿美元。
A total of 271 patients were prospectively followed up to determine whether patients whose hospital stay is complicated by diarrhea due to Clostridium difficile experience differences in cost and length of stay and survival rates when compared with patients whose stay is not complicated by C. difficile-associated diarrhea. Forty patients (15%) developed nosocomial C. difficile-associated diarrhea. These patients incurred adjusted hospital costs of $3669-that is, 54% (95% confidence interval [CI], 17%-103%)-higher than patients whose course was not complicated by C. difficile-associated diarrhea. The extra length of stay attributable to C. difficile-associated diarrhea was 3.6 days (95% CI, 1.5-6.2). C. difficile-associated diarrhea was not associated with excess 3-month or 1-year mortality after adjustment for age, comorbidity, and disease severity. On the basis of the findings of this study, a conservative estimate of the cost of this disease in the United States exceeds $1.1 billion per year.