The impact of overactive bladder on mental health, work productivity and health-related quality of life in the UK and Sweden: results from EpiLUTS
The impact of overactive bladder on mental health, work productivity and health-related quality of life in the UK and Sweden: results from EpiLUTS
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DOI：
10.1111/j.1464-410x.2010.10013.x
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发表时间：
2011-11-01
影响因子：
4.5
通讯作者：
Chapple, Chris
中科院分区：
文献类型：
--
作者：
Coyne, Karin S.;Sexton, Chris C.;Chapple, Chris
目的：研究英国和瑞典膀胱过度活动症（OAB）的患病率和负担，并与无困扰的OAB和无/最小OAB/下尿路（LUTS）症状进行比较，分别在英国，瑞典和美国通过互联网进行横断面人群代表性调查。患者结局包括膀胱过度活动问卷简表、患者对膀胱状况的感知简表-12、医院焦虑和抑郁量表-焦虑和医院焦虑和抑郁量表-抑郁，以及关于寻求治疗和工作效率的问题。比较了三个亚组：无/轻微症状、无困扰和有困扰的OAB。使用一般线性和逻辑回归模型按性别和国家进行分析，以检查令人烦恼的OAB和寻求治疗。1万人（4724名男性和5276名女性）参与了研究。在英国和瑞典，男性中至少有“某种程度”困扰的OAB患病率分别为10.9%和14.6%，英国和瑞典的女性分别为22.5%和33.7%。与没有/最小症状和OAB无困扰的人相比，患有令人烦恼的OAB的男性和女性更有可能寻求治疗，报告最低水平的健康相关生活质量和工作效率以及最高水平的焦虑和抑郁。频率、焦虑和焦虑水平的增加是男性和女性OAB困扰的强预测因子。寻求治疗的预测因子包括频率、由于紧迫性而引起的困扰和男性抑郁症状的较低水平，以及频率、焦虑和紧迫性在女性中的预测因子。女性比男性更容易受到影响。OAB的影响在健康相关生活质量的一般和特定条件领域都很明显。
OBJECTIVETo examine the prevalence and burden of overactive bladder (OAB) with bother in the UK and Sweden compared to OAB without bother and no/minimal OAB/lower urinary tract (LUTS) symptoms, respectively.PATIENTS AND METHODSA cross-sectional population-representative survey was conducted via the Internet in the UK, Sweden and USA.Participants rated the frequency and bother of OAB and LUTS. Patient outcomes included the Overactive Bladder Questionnaire Short Form, Patient Perception of Bladder Condition, Short Form-12, Hospital Anxiety and Depression Scale-Anxiety and Hospital Anxiety and Depression Scale-Depression, as well as questions about treatment seeking and work productivity.OAB was defined as urgency at least sometimes or the presence of urinary urgency incontinence. Three subgroups were compared: no/minimal symptoms, OAB without bother and OAB with bother.Analyses were conducted by gender and country using general linear and logistic regression models to examine bothersome OAB and treatment seeking.RESULTSSurvey response was 59.2%; 10 000 people (4724 men and 5276 women) participated.The prevalence of OAB with bother at least 'somewhat' was 10.9% and 14.6% for men in the UK and Sweden, and 22.5% and 33.7% for women in the UK and Sweden, respectively.Men and women with bothersome OAB were significantly more likely to seek treatment, report the lowest levels of health-related quality of life and work productivity and the highest levels of anxiety and depression compared to those with no/minimal symptoms and OAB without bother.Greater symptom severity of urgency, urgency urinary incontinence, frequency, nocturia, and increasing levels of anxiety were strongly predictive of OAB bother in both men and women.Predictors of treatment seeking included frequency, bother as a result of urgency, and lower levels of depressive symptoms in men, and frequency, nocturia and urgency in women.CONCLUSIONSOAB is common in the UK and Sweden, and women are more likely to be affected then men.The impact of OAB is evident across generic and condition-specific domains of health-related quality of life.