Pattern of Visual Field Loss in Primary Angle-Closure Glaucoma Across Different Severity Levels
Pattern of Visual Field Loss in Primary Angle-Closure Glaucoma Across Different Severity Levels
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DOI：
10.1016/j.ophtha.2016.05.026
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发表时间：
2016-09-01
期刊：
影响因子：
13.7
通讯作者：
Aung, Tin
中科院分区：
文献类型：
--
作者：
Atalay, Eray;Nongpiur, Monisha E.;Aung, Tin
目的：研究原发性闭角型青光眼（PACG）不同严重程度的视野（VF）缺损模式，并评估每个严重程度内的半视野差异。设计：横断面研究。参与者：304例确诊为PACG的患者从新加坡医院的青光眼诊所招募。根据静态自动视野检查（瑞典交互阈值算法标准程序24-2; Humphrey型号750 [Carl Zeiss Meditec，都柏林，CA]）原理记录逐点总偏差值。如果患者的VF不可靠（固视丢失>33%，假阳性反应>15%），仅进行了10-2 VF测试，具有非典型青光眼的VF缺陷，或接受了白内障摘除术，则将其排除在外。轻度、中度和重度VF丧失分别定义为平均偏差为-6.00 dB或更高、-6.01至-12.00 dB和-12.01 dB或更低。根据青光眼半视野测试扇区将每个半视野划分为区域。每个区域的平均平均偏差（MD）获得使用总偏差values.Main结果措施：之间和内半野差异的严重程度levels.Results的区域：排除不合格的情况下，249例PACG患者被纳入分析。患者的平均年龄为65.7 ± 8.6岁，性别比为1：1。轻度、中度和重度VF的患者数量分别为72例（28.9%）、78例（31.3%）和99例（39.8%）。对于半野间比较，在严重度范围内，与下半野中的对应区域相比，上级半野中的所有区域的MD更差。同样，内hemifields比较，MD的区域逐渐恶化，距离fixation point.Conclusions：在这组临床为基础的PACG患者，上级hemifields被发现受到更严重的影响比下级hemifields，和他们之间的差异增加，恶化的疾病严重程度。鼻区的损伤一直比较明显。美国眼科学会2016年眼科学（C）。
Purpose: To investigate the patterns of visual field (VF) defects in primary angle-closure glaucoma (PACG) across different severity levels and to assess hemifield differences within each severity level.Design: Cross-sectional study.Participants: Three hundred four patients diagnosed with PACG were recruited from glaucoma clinics at a Singapore hospital.Methods: Point-wise total deviation values were recorded from the static automated perimetry (Swedish interactive threshold algorithm standard program 24-2; Humphrey model 750 [Carl Zeiss Meditec, Dublin, CA]) printouts. Patients were excluded if they had unreliable VFs (fixation losses >33% and false-positive responses >15%), had undergone only 10-2 VF testing, had VF defects not typical of glaucoma, or had undergone cataract extraction. Mild, moderate, and severe VF loss were defined by a mean deviation of -6.00 dB or more, -6.01 to -12.00 dB, and -12.01 dB or less, respectively. Each hemifield was divided into regions according to glaucoma hemifield test sectors. The average mean deviation (MD) of each region was obtained using total deviation values.Main Outcome Measures: Between-and within-hemifield differences of the regions across the severity levels.Results: After excluding ineligible cases, 249 patients with PACG were included in the analysis. Mean age of the patients was 65.7 +/- 8.6 years, with a 1:1 gender ratio. The number of patients who had mild, moderate, and severe VFs was 72 (28.9%), 78 (31.3%), and 99 (39.8%), respectively. For between-hemifield comparisons, all regions in the superior hemifield had worse MDs compared with their counterparts in the inferior hemifield across the severity spectrum. Likewise, for within-hemifield comparisons, MDs of the regions gradually worsened with increasing distance from the fixation point.Conclusions: In this group of clinic-based PACG patients, the superior hemifield was found to be affected more severely than the inferior hemifield, and the differences between them increased with worsening disease severity. The damage was consistently more pronounced in the nasal area. Ophthalmology (C) 2016 by the American Academy of Ophthalmology.