Dexamethasone pulse therapy in severe long-standing alopecia areata : a treatment failure
Dexamethasone pulse therapy in severe long-standing alopecia areata : a treatment failure
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地塞米松脉冲疗法治疗严重的长期斑秃：治疗失败
DOI：
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发表时间：
1996
影响因子：
2.5
通讯作者：
E. Bröcker
中科院分区：
文献类型：
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作者：
A. Schulz;H. Hamm;U. Weiglein;M. Axt;E. Bröcker
对9例重度长期性斑秃（AA）患者进行地塞米松重复脉冲治疗（100mg静脉滴注，每4周3天），其中5例为至少0%斑秃，4例为全发性或全发性脱发。患者年龄16 ~ 56岁（平均36岁）。其中8名女性，1名男性。在地塞米松脉冲治疗之前，疾病的总持续时间平均为14年（14个月至41年）。患者接受4 ~ 10个周期（平均6个周期）地塞米松脉冲治疗。在治疗期间，只有一名患者表现出良好的，但暂时的反应（6个月后再生30%）。治疗结束后，2名患者的最大再生率低于5%，而其他6名患者没有改善或进一步脱发。总之，反复使用地塞米松治疗长期、严重形式的患者效果不理想。
Nine patients with severe long-standing alopecia areata (AA) including 5 patients with at least 0% patchy scalp hair loss and 4 patients with alopecia totalis or universalis, were treated with repeated pulses of dexamethasone (100 mg i.v. daily for 3 days every 4 weeks). The patients were 16-56 years of age (mean: 36 years). Eight were female and one was male. The total duration of the disease prior to the dexamethasone pulse therapy averaged 14 years (14 months to 41 years). The patients received 4 to 10 cycles (mean: 6 cycles) of dexamethasone pulses. During the treatment only one patient showed a good, but temporary response (30% regrowth after 6 months). After the end of the treatment 2 patients developed a maximum regrowth of less than 5%, while no improvement or further hair loss was observed in the other 6 patients. In conclusion, treatment of patients suffering from long-standing, severe forms of with repeated pulses of dexamethasone gave unsatisfactory results.