Monitoring concussion in a knocked-out boxer by CSF biomarker analysis
Monitoring concussion in a knocked-out boxer by CSF biomarker analysis
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DOI：
10.1007/s00167-014-3066-6
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发表时间：
2015-09-01
影响因子：
3.8
通讯作者：
Blennow, Kaj
中科院分区：
文献类型：
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作者：
Neselius, Sanna;Brisby, Helena;Blennow, Kaj
脑震荡在许多运动项目中很常见，且发病率呈上升趋势。近年来，运动相关脑震荡后的医疗后果受到越来越多的关注，因为众所周知，脑震荡会导致轴突和神经胶质损伤，这会扰乱大脑生理机能，使大脑更容易受到额外的脑震荡。本研究报告了一名被击倒的业余拳击手，其脑脊液（CSF）神经丝光（NFL）蛋白反映了轴突损伤，用于识别和监测脑损伤。CSF NFL在36周内显著增加，表明脑震荡后神经元损伤持续的时间比预期的要长。CSF生物标志物分析可能对脑震荡运动员的医疗咨询和重返赛场的考虑有价值。证据等级IV。
Concussion is common in many sports, and the incidence is increasing. The medical consequences after a sport-related concussion have received increased attention in recent years since it is known that concussions cause axonal and glial damage, which disturbs the cerebral physiology and makes the brain more vulnerable for additional concussions. This study reports on a knocked-out amateur boxer in whom cerebrospinal fluid (CSF) neurofilament light (NFL) protein, reflecting axonal damage, was used to identify and monitor brain damage. CSF NFL was markedly increased during 36 weeks, suggesting that neuronal injury persists longer than expected after a concussion. CSF biomarker analysis may be valuable in the medical counselling of concussed athletes and in return-to-play considerations.Level of evidence IV.