Keratitis caused by Candida glabrata in a patient with chronic granulomatous disease
Keratitis caused by Candida glabrata in a patient with chronic granulomatous disease
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DOI：
10.1016/s0002-9394(01)01091-1
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发表时间：
2001-11-01
影响因子：
4.2
通讯作者：
Robinson, MR
中科院分区：
文献类型：
--
作者：
Djalilian, AR;Smith, JA;Robinson, MR
目的：报告一名慢性肉芽肿病患者的光滑念珠菌异常眼部表现。方法：干预病例报告。一名 15 岁男孩患有慢性肉芽肿病，表现为双侧角膜缘浸润。他一直在接受广谱全身抗生素治疗复发性肝脓肿。角膜炎对抗生素没有反应，并且在局部类固醇治疗后也没有缓解。结果：角膜培养显示光滑念珠菌。肝脓肿手术引流中同时分离出同一物种。静脉注射两性霉素 B 后，眼部和肝脏的检查结果得以解决。结论：光滑念珠菌最近已成为一种重要的医院病原体。在全身感染的情况下，它可能表现为角膜缘角膜炎。 (C) 2001 年，Elsevier Science Inc. 保留所有权利。
PURPOSE: To report an unusual ocular presentation of Candida glabrata in a patient with chronic granulomatous disease.METHODS: Interventional case report. A 15-year-old boy with chronic granulomatous disease presented with bilateral limbal infiltrates. He had been receiving broad-spectrum systemic antibiotics for recurrent liver abscesses. The keratitis did not respond to antibiotics and did not resolve after a course of topical steroids.RESULTS: Corneal cultures revealed Candida glabrata. The same species was simultaneously isolated from the surgical drainage of the liver abscesses. The ocular and hepatic findings resolved on intravenous amphotericin B.CONCLUSION: Candida glabrata has recently emerged as an important nosocomial pathogen. It may present as a limbal keratitis in the setting of systemic infection. (C) 2001 by Elsevier Science Inc. All rights reserved.