On the Road to Biopolymer Aerogels-Dealing with the Solvent
On the Road to Biopolymer Aerogels-Dealing with the Solvent
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DOI：
10.3390/gels1020291
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发表时间：
2015-12-01
期刊：
影响因子：
4.6
通讯作者：
Smirnova, Irma
中科院分区：
文献类型：
--
作者：
Subrahmanyam, Raman;Gurikov, Pavel;Smirnova, Irma
气凝胶是三维超轻多孔结构，其特性使其成为研究，开发和商业化的令人兴奋的候选者，从而导致从绝缘和催化到再生医学和制药的广泛应用。生物聚合物最近进入了气凝胶领域。为了充分发挥其潜力，必须制定处理生产时间和降低成本的渐进策略，以促进气凝胶生产从实验室规模扩大到商业规模。本文以海藻酸钙为模型体系，提出了研究溶剂交换和超临界CO2干燥过程中溶剂/基质相互作用的必要性。四个框架，即（a）溶剂/聚合物相互作用的基础上选择溶剂的方法;（B）溶剂交换过程中的浓度梯度的影响;（c）溶剂交换动力学的基础上伪二阶模型;和（d）超临界CO2干燥的最低溶剂浓度要求，建议，可以帮助评估的作用，在生物聚合物气凝胶生产中的溶剂。
Aerogels are three-dimensional ultra-light porous structures whose characteristics make them exciting candidates for research, development and commercialization leading to a broad scope of applications ranging from insulation and catalysis to regenerative medicine and pharmaceuticals. Biopolymers have recently entered the aerogel foray. In order to fully realize their potential, progressive strategies dealing with production times and costs reduction must be put in place to facilitate the scale up of aerogel production from lab to commercial scale. The necessity of studying solvent/matrix interactions during solvent exchange and supercritical CO2 drying is presented in this study using calcium alginate as a model system. Four frameworks, namely (a) solvent selection methodology based on solvent/polymer interaction; (b) concentration gradient influence during solvent exchange; (c) solvent exchange kinetics based on pseudo second order model; and (d) minimum solvent concentration requirements for supercritical CO2 drying, are suggested that could help assess the role of the solvent in biopolymer aerogel production.