Effect of aspirin on N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced epithelial proliferation in the urinary bladder and forestomach of the rat.
Effect of aspirin on N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced epithelial proliferation in the urinary bladder and forestomach of the rat.
复制标题
阿司匹林对 N-[4-(5-硝基-2-呋喃基)-2-噻唑基]-甲酰胺诱导的大鼠膀胱和前胃上皮增殖的影响。
DOI：
10.1016/0304-3835(84)90005-3
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发表时间：
1984
期刊：
影响因子：
9.7
通讯作者：
Cohen,SM
中科院分区：
文献类型：
--
作者：
Hasegawa,R;StJohn,M;Murasaki,G;Fukushima,S;Cohen,SM
阿司匹林与N-[4-（5-硝基-2-呋喃基）-2-噻唑基]-甲酰胺（FANFT）联合给药可降低FANFT诱导的膀胱癌的发生率，但同时诱导前胃肿瘤。对喂食含0.2%水平FANFT和/或0.5%水平阿司匹林的饲料的雄性F-344大鼠进行放射自显影研究，以评价阿司匹林对FANFT诱导的前胃和膀胱细胞增殖增加的影响。FANFT诱导的膀胱细胞增殖在4周后被阿司匹林联合给药显著抑制，但在12周后没有。在前胃和肝脏中，阿司匹林不影响FANFT诱导的标记指数增加。目前的结果是一致的致癌性实验表明，不同的机制参与FANFT在膀胱和前胃的致癌作用，阿司匹林对FANFT在前胃的影响是不是由于刺激作用与细胞增殖增加。此外，大鼠似乎对长期摄入阿司匹林有适应性。
The co-administration of aspirin withN-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT) to rats resulted in a reduced incidence of FANFT-induced bladder carcinomas but a concomitant induction of forestomach tumors. An autoradiographic study was performed on male F-344 rats fed diet containing FANFT at a level of 0.2% and/or aspirin at a level of 0.5% to evaluate the effect of aspirin on the increased cell proliferation induced by FANFT in the forestomach and bladder. FANFT-induced cell proliferation in the bladder was significantly suppressed by aspirin co-administration after 4 weeks but not after 12 weeks. In the forestomach, and also in the liver, aspirin did not affect the FANFT-induced increase in labeling index. The present results are consistent with the carcinogenicity experiment suggesting that different mechanisms are involved in FANFT carcinogenesis in the bladder and forestomach, and that aspirin's effect on FANFT in the forestomach is not due to an irritant effect associated with increased cell proliferation. Also, there appears to be an adaptation by the rats to the chronic ingestion of aspirin.