MARINE NATURAL-PRODUCTS - PYRROLOLACTAMS FROM SEVERAL SPONGES
MARINE NATURAL-PRODUCTS - PYRROLOLACTAMS FROM SEVERAL SPONGES
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DOI：
10.1021/np50037a008
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发表时间：
1985-01-01
影响因子：
5.1
通讯作者：
TILLEKERATNE, LMV
中科院分区：
文献类型：
--
作者：
SCHMITZ, FJ;GUNASEKERA, SP;TILLEKERATNE, LMV
从几种海绵[Hymeniacidon aldis和lissodendoryx]中分离出两种吡咯内酰胺，可能是更复杂的已知胍的降解产物。还分离出5-溴-和4，5-二溴吡咯-1-羧酸甲酯。发现一种难溶于DMSO [二甲基亚砜]的复杂胍代谢物在酸性介质中可产生清晰、重现的NMR光谱。[这些代谢物的细胞毒性特性的影响。
Two pyrrololactams, likely degradation products of more complex known guanidines, were isolated from several marine sponges [Hymeniacidon aldis and lissodendoryx]. 5-Bromo- and 4,5-dibromopyrrole-1-carboxylic acid methyl esters were also isolated. A complex guanidine metabolite, poorly soluble in DMSO [dimethyl sulfoxide], was found to give sharp, resproducible NMR spectra in acid media. [Implications with respect to the cytotoxic properties of these metabolites were presented.