The protein shells of bacterial microcompartment organelles.
The protein shells of bacterial microcompartment organelles.
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DOI：
10.1016/j.sbi.2011.01.006
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发表时间：
2011-04
影响因子：
6.8
通讯作者：
Bobik TA
中科院分区：
文献类型：
--
作者：
Yeates TO;Thompson MC;Bobik TA
在许多细菌中作为简单的代谢细胞器的一类非凡的captlets样蛋白质组装体的结构和功能的细节正在出现。这些细菌微区室由几千个壳蛋白组成，它们封装了两种或更多种顺序作用的酶，以增强或隔离某些代谢途径，特别是那些涉及有毒或挥发性中间体的代谢途径。基因组数据表明，细菌微区室壳蛋白存在于广泛的细菌物种中，在那里它们封装不同的反应。来自不同类型的微区室的许多壳蛋白的晶体结构为理解壳如何组装以及它们如何进行分子运输进出微区室提供了关键。结构数据强调了高水平的机械复杂的蛋白质外壳，并指出了进一步研究这一迷人的，但不太赞赏类亚细胞结构的方式。
Details are emerging on the structure and function of a remarkable class of capsid-like protein assemblies that serve as simple metabolic organelles in many bacteria. These bacterial microcompartments consist of a few thousand shell proteins, which encapsulate two or more sequentially acting enzymes in order to enhance or sequester certain metabolic pathways, particularly those involving toxic or volatile intermediates. Genomic data indicate that bacterial microcompartment shell proteins are present in a wide range of bacterial species, where they encapsulate varied reactions. Crystal structures of numerous shell proteins from distinct types of microcompartments have provided keys for understanding how the shells are assembled and how they conduct molecular transport into and out of microcompartments. The structural data emphasize a high level of mechanistic sophistication in the protein shell, and point the way for further studies on this fascinating but poorly appreciated class of subcellular structures.