mokapot: Fast and Flexible Semisupervised Learning for Peptide Detection.
mokapot: Fast and Flexible Semisupervised Learning for Peptide Detection.
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DOI：
10.1021/acs.jproteome.0c01010
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发表时间：
2021-04-02
影响因子：
4.4
通讯作者：
Noble WS
中科院分区：
文献类型：
--
作者：
Fondrie WE;Noble WS
蛋白质组学研究依赖于肽的准确分配，以获得串联质谱-机器学习算法已被证明是无价的任务。我们描述mokapot，它提供了一个灵活的半监督学习算法，允许高度定制的分析。我们证明了一些独特的功能mokapot通过改善检测RNA交联肽从RNA结合蛋白的分析，并增加了肽检测的一致性，在单细胞蛋白质组学研究。
Proteomics studies rely on the accurate assignment of peptides to the acquired tandem mass spectra—a task where machine learning algorithms have proven invaluable. We describe mokapot, which provides a flexible semisupervised learning algorithm that allows for highly customized analyses. We demonstrate some of the unique features of mokapot by improving the detection of RNA-cross-linked peptides from an analysis of RNA-binding proteins and increasing the consistency of peptide detection in a single-cell proteomics study.
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影响因子：
64.8
作者：
Kim, Min-Sik;Pinto, Sneha M.;Getnet, Derese;Nirujogi, Raja Sekhar;Manda, Srikanth S.;Chaerkady, Raghothama;Madugundu, Anil K.;Kelkar, Dhanashree S.;Isserlin, Ruth;Jain, Shobhit;Thomas, Joji K.;Muthusamy, Babylakshmi;Leal-Rojas, Pamela;Kumar, Praveen;Sahasrabuddhe, Nandini A.;Balakrishnan, Lavanya;Advani, Jayshree;George, Bijesh;Renuse, Santosh;Selvan, Lakshmi Dhevi N.;Patil, Arun H.;Nanjappa, Vishalakshi;Radhakrishnan, Aneesha;Prasad, Samarjeet;Subbannayya, Tejaswini;Raju, Rajesh;Kumar, Manish;Sreenivasamurthy, Sreelakshmi K.;Marimuthu, Arivusudar;Sathe, Gajanan J.;Chavan, Sandip;Datta, Keshava K.;Subbannayya, Yashwanth;Sahu, Apeksha;Yelamanchi, Soujanya D.;Jayaram, Savita;Rajagopalan, Pavithra;Sharma, Jyoti;Murthy, Krishna R.;Syed, Nazia;Goel, Renu;Khan, Aafaque A.;Ahmad, Sartaj;Dey, Gourav;Mudgal, Keshav;Chatterjee, Aditi;Huang, Tai-Chung;Zhong, Jun;Wu, Xinyan;Shaw, Patrick G.;Freed, Donald;Zahari, Muhammad S.;Mukherjee, Kanchan K.;Shankar, Subramanian;Mahadevan, Anita;Lam, Henry;Mitchell, Christopher J.;Shankar, Susarla Krishna;Satishchandra, Parthasarathy;Schroeder, John T.;Sirdeshmukh, Ravi;Maitra, Anirban;Leach, Steven D.;Drake, Charles G.;Halushka, Marc K.;Prasad, T. S. Keshava;Hruban, Ralph H.;Kerr, Candace L.;Bader, Gary D.;Iacobuzio-Donahue, Christine A.;Gowda, Harsha;Pandey, Akhilesh
通讯作者：
Pandey, Akhilesh
影响因子：
4.4
作者：
Tu C;Sheng Q;Li J;Ma D;Shen X;Wang X;Shyr Y;Yi Z;Qu J
通讯作者：
Qu J
影响因子：
3
作者：
Granholm V;Noble WS;Käll L
通讯作者：
Käll L
影响因子：
4.4
作者：
Hulstaert, Niels;Shofstahl, Jim;Perez-Riverol, Yasset
通讯作者：
Perez-Riverol, Yasset
影响因子：
14.9
作者：
Vizcaíno JA;Csordas A;del-Toro N;Dianes JA;Griss J;Lavidas I;Mayer G;Perez-Riverol Y;Reisinger F;Ternent T;Xu QW;Wang R;Hermjakob H
通讯作者：
Hermjakob H