Synthesis, self-assembly and drug release behaviors of pH-responsive copolymers ethyl cellulose-graft-PDEAEMA through ATRP
Synthesis, self-assembly and drug release behaviors of pH-responsive copolymers ethyl cellulose-graft-PDEAEMA through ATRP
复制标题
ATRP 乙基纤维素-接枝-PDEAEMA pH 响应型共聚物的合成、自组装及药物释放行为
DOI：
10.1016/j.carbpol.2010.11.023
复制
发表时间：
2011-02-11
影响因子：
11.2
通讯作者：
Huang, Yong
中科院分区：
文献类型：
--
作者：
Wang, Deqian;Tan, Junjun;Huang, Yong
通过原子转移自由基聚合（ATRP）合成了pH响应性乙基纤维素接枝聚甲基丙烯酸二乙氨基乙酯（EC-g-PDEAEMA）共聚物。动力学分析证实了该反应是活性的、可控的。接枝共聚物在酸性水溶液中能形成胶束。接枝共聚物的临界胶束浓度（CMC）随接枝长度和接枝密度的增加而降低。所得胶束显示pH敏感性。在pH 6-6.9范围内胶束流体动力学半径的减小归因于由于去质子化导致胶束壳中侧链PDEAEMA的坍塌，这通过TEM观察进一步证实。以利福平（RIF）为模型药物，研究了胶束对药物的负载和控制释放。结果表明，在pH 6.6的缓冲溶液中，RIF的累积释放量高于pH 7.4。(C)2010爱思唯尔有限公司保留所有权利。
The pH-responsive ethyl cellulose graft poly(2-(diethylamino) ethyl methacrylate) (EC-g-PDEAEMA) copolymers were synthesized through atom transfer radical polymerization (ATRP). Kinetic analysis confirmed the reaction is living and controllable. The graft copolymers can form micelles in acid aqueous medium. The critical micelle concentration (CMC) of the graft copolymers decreases with the increase of the graft length and graft density. The resultant micelles show the pH-sensitivity. The decrease in the hydrodynamic radius of the micelles at pH 6-6.9 attributes to collapse of the side PDEAEMA chains in the shell of the micelles due to the deprotonation, which was further confirmed by TEM observation. The loading and controlled release of drugs in the micelles was investigated by using rifampicin (RIF) as the model drug. It was found that the cumulant release of RIF in the buffer solution at pH 6.6 is higher than that at pH 7.4. (C) 2010 Elsevier Ltd. All rights reserved.