Absence of adverse early quality of life outcomes of radiation therapy in breast conservation therapy for early breast cancer.
Absence of adverse early quality of life outcomes of radiation therapy in breast conservation therapy for early breast cancer.
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DOI：
10.1111/j.1440-1673.2005.01392.x
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发表时间：
2005-02-01
期刊：
影响因子：
--
通讯作者：
Wratten, C
中科院分区：
文献类型：
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作者：
Back, M;Ahern, V;Wratten, C
新南威尔士州乳腺放射肿瘤学小组已经完成了一项前瞻性多中心研究，研究放射治疗（RT）对早期乳腺癌妇女接受保乳治疗的急性毒性和生活质量（QoL）的影响。患者组在乳腺癌广泛局部切除后接受辅助乳腺切线放疗。急性毒性和美观性进行了定量和定性评估。采用欧洲癌症研究和治疗组织生活质量问卷（EORTC QLQ-30）和感知慢性病适应量表（PACIS）作为生活质量工具。在175名女性中，34.3%描述了嗜睡导致RT期间正常活动的显著中断。在第6周，这一比例降至7.5%，报告了显著嗜睡。RT期间未观察到对QoL的负面影响; EORTC显示无差异（P = 0.79）。PACIS记录了从基线到第6周的功能显著改善（P < 0.001）。对潜在预测患者、肿瘤和治疗因素的单变量分析表明，基线RT前乳房不适与嗜睡（P = 0.03）、EORTC（P < 0.01）和PACIS（P < 0.01）指标相关。这项研究证实了RT在治疗后6周对患者功能的影响很小。
The New South Wales Breast Radiation Oncology Group has completed a prospective multicentre study of the impact of radiation therapy (RT) on acute toxicity and quality of life (QoL) in women with early breast cancer treated with breast conservation therapy. The patient group received adjuvant breast tangential RT after wide local excision of breast cancer. Acute toxicity and cosmesis was assessed quantitatively and qualitatively. European Organization of Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-30) and Perceived Adjustment to Chronic Illness Scale (PACIS) were the QoL instruments used. Of 175 women, 34.3% described lethargy leading to a significant disruption to normal activity during RT. At week 6, this had reduced to 7.5% reporting significant lethargy. No negative effects on QoL were noted over the time period of RT; EORTC demonstrated no difference (P = 0.79). PACIS recorded a significant improvement in functioning (P < 0.001) from baseline to week 6. Univariate analysis on potential predictive patient, tumour and treatment factors demonstrated an association of baseline pre-RT breast discomfort with worse lethargy (P = 0.03), EORTC (P < 0.01) and PACIS (P < 0.01) measures. This study confirms the minimal impact of RT on patient functioning at 6 weeks post-treatment.