Mutual tolerization of histoincompatible lymphocytes
Mutual tolerization of histoincompatible lymphocytes
复制标题
组织不相容淋巴细胞的相互耐受
DOI：
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发表时间：
1987
影响因子：
5.4
通讯作者：
M. Bevan
中科院分区：
文献类型：
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作者：
H. Rammensee;M. Bevan
T lymphocytes react strongly against foreign major histocompatibility complex encoded class I antigens by destroying incompatible tissue in vivo, and by generating cytotoxic T lymphocytes (CTL) in vitro. The absence of reactivity against self antigens may be due to clonal deletion of self‐reactive T cells during their ontogeny in the thymus. The functional clonal deletion of mature T cells in the periphery was described recently: CTL recognizing antigen on other CTL are eliminated (Rammensee et al., Immunol. Today 1985. 6: 41). Hence, in a normal immune system only autoreactive cells would be eliminated. Here we show that injection of lymphocytes into class I‐incompatible mice leads to abrogation of host anti‐donor as well as donor anti‐host reactivity, leaving a mixed population of host and donor T cells reactive against third‐party antigens. The results demonstrate the existence of a peripheral failsafe mechanism for the elimination of autoaggressive CTL. Whether this failsafe mechanism is actually used under physiological conditions is a different question.
通过表达抗原的否决细胞对 I 类特异性细胞毒性 T 淋巴细胞进行功能性克隆删除。
DOI：
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发表时间：
1984
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Rammensee,HG;Fink,PJ;Bevan,MJ
通讯作者：
Bevan,MJ
克隆的溶细胞 T 细胞可以抑制针对它们的初级细胞毒性反应。
DOI：
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发表时间：
1984
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Fink,PJ;Rammensee,HG;Bevan,MJ
通讯作者：
Bevan,MJ
克隆细胞毒性T淋巴细胞抑制原代细胞毒性反应机制的研究。
DOI：
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发表时间：
1984
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Fink,PJ;Rammensee,HG;Benedetto,JD;Staerz,UD;Lefrancois,L;Bevan,MJ
通讯作者：
Bevan,MJ